Reaction profile

The FDA adverse-event record for hypertrophic osteodystrophy

17 FDA adverse-event reports reference hypertrophic osteodystrophy (VeDDRA 2124). See the species, breeds, and drugs most associated with it below.

17
reports citing this reaction
11.8%
death-coded share
Dog
most-affected species
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St
most-associated drug
Verify with FDA CVM →
17
Total Reports
2
Deaths
11.8%
Death Rate

Species Most Affected

Dog 17

Breeds Most Affected

Weimaraner 3
Retriever - Labrador 2
Shepherd Dog - German 2
Crossbred Canine/dog 2
Deutsche Dogge, Great Dane 2
Great Pyrenees 1
Pointer (unspecified) 1
Retriever (unspecified) 1
Cattle Dog - Flanders (Bouvier) 1
Poodle (unspecified) 1

Associated Drugs

Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 5
Milbemycin Oxime + Spinosad 4
Maropitant Citrate 3
Pyrantel Pamoate (Pyrantel Embonate) 2
Selamectin 2
Ampicillin Trihydrate 2
Metronidazole 2
Robenacoxib 2
Afoxolaner 2
Milbemycin Oxime + Praziquantel 2
Pyrantel Pamoate;Sarolaner 2
Spinosad 1
Ivermectin + Pyrantel Pamoate + Praziquantel 1
Ivermectin 1
Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate) 1
Dapp 1
Bordetella Bronchiseptica Vaccine 1
Canine Coronavirus, Strain Nl-18, Ms-P40 Lot #1, 9-29-82 1
Amoxicillin 1
Oclacitinib Maleate 1

Hypertrophic osteodystrophy Reaction Insights

17 reports name Hypertrophic osteodystrophy; 2 recorded a death outcome (11.8% of reported events, not a population-level mortality rate). VeDDRA code: 2124.

By species: Dog (17 reports). By breed: Weimaraner (3), Retriever - Labrador (2), Shepherd Dog - German (2).

Most co-reported drugs: Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St (5 reports), Milbemycin Oxime + Spinosad (4 reports), Maropitant Citrate (3 reports), Pyrantel Pamoate (Pyrantel Embonate) (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.