Reaction profile

The FDA adverse-event record for hypercalcaemic condition

16 FDA adverse-event reports reference hypercalcaemic condition (VeDDRA 2687). See the species, breeds, and drugs most associated with it below.

16
reports citing this reaction
31.3%
death-coded share
Dog
most-affected species
Velagliflozin Proline Monohydrate
most-associated drug
Verify with FDA CVM →
16
Total Reports
5
Deaths
31.3%
Death Rate

Species Most Affected

Dog 9
Cat 7

Breeds Most Affected

Domestic Shorthair 4
Domestic Mediumhair 3
Dog (unknown) 2
Retriever - Labrador 2
Shih Tzu 1
Great Pyrenees 1
Pit Bull 1
Collie - Border 1
Shepherd Dog - German 1

Associated Drugs

Velagliflozin Proline Monohydrate 5
Afoxolaner 4
Ivermectin + Pyrantel As Pamoate Salt 2
Milbemycin Oxime + Praziquantel 2
Dexmedetomidine Hydrochloride 2
Telmisartan 1
Firocoxib 1
Fluralaner 13.64% 12-Week Chew 1
Grapiprant 1
Atipamezole Hydrochloride 1
Anti-Il31 Mab Mcs Lot 283563 1
Bedinvetmab 1
Butorphaol 1
Frunevetmab 1
Senvelgo Velagliflozin Oral Solution 1
Isoflurane 1
Carprofen 1
Maropitant Citrate 1
Omeprazole 1
Ampicillin 1

Hypercalcaemic condition Reaction Insights

16 reports name Hypercalcaemic condition; 5 recorded a death outcome (31.3% of reported events, not a population-level mortality rate). VeDDRA code: 2687.

By species: Dog (9 reports), Cat (7 reports). By breed: Domestic Shorthair (4), Domestic Mediumhair (3), Dog (unknown) (2).

Most co-reported drugs: Velagliflozin Proline Monohydrate (5 reports), Afoxolaner (4 reports), Ivermectin + Pyrantel As Pamoate Salt (2 reports), Milbemycin Oxime + Praziquantel (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.