Reaction profile

The FDA adverse-event record for hypercalcaemic condition

17 FDA reports name hypercalcaemic condition, a lower-volume reaction in the CVM extract (VeDDRA 2687). Plate stamps and neighbourhood peers follow.

#2242 of 2,481
by report volume (all reactions)
17
reports citing this reaction
29.4%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hypercalcaemic condition has 17 reports now versus 16 in that prior snapshot: 1 more (6.3%).

Report change
+1
Death-coded reports
+0
Death-coded share
−1.8 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hypercalcaemic condition changes

FDA AER · VeDDRA plate

Code 2687 VOL-TRACE

VOL-TRACE · DEATH-HOT · BOTTOM-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 17 reports
  • DEATH-HOT 29.4%
  • BOTTOM-DECILE #2242/2481
  • PHOTO-FINISH Anoestrus
  • SPECIES-DOG Dog · 9
  • DRUG-LEAD Velagliflozin Pro… · 6
  • DESK-WIDE 10 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Anoestrus (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Hypercalcaemic condition

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Anoestrus · near17Bone nonunion, medica… · near17Cardiac insufficiency · near17Cerebral vascular acc… · near17Hypercalcaemic condit… · thi…17Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Hypercalcaemic condition

Hypercalcaemic condition: high death-coded share in the FDA AER plate

Signature read: 17 reports place Hypercalcaemic condition in the lower third of FDA AER volume (#2242 of 2,481). Report volume is lower-third scale: 17 named reports in the openFDA extract. Death-coded share is upper-third: 5 of 17 reports (29.4% of named reports). Nearest volume peer: Anoestrus (±0 reports). Lead species Dog (9). Lead co-reported drug Velagliflozin Proline Monohydrate (6).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 9
Cat 8

Breeds Most Affected

Domestic Shorthair 4
Domestic Mediumhair 3
Dog (unknown) 2
Retriever - Labrador 2
Shih Tzu 1
Great Pyrenees 1
Collie - Border 1
Pit Bull 1
Shepherd Dog - German 1
Domestic Longhair 1

Associated Drugs

Velagliflozin Proline Monohydrate 6
Afoxolaner 4
Ivermectin + Pyrantel As Pamoate Salt 2
Milbemycin Oxime + Praziquantel 2
Dexmedetomidine Hydrochloride 2
Telmisartan 1
Firocoxib 1
Fluralaner 13.64% 12-Week Chew 1
Grapiprant 1
Atipamezole Hydrochloride 1
Anti-Il31 Mab Mcs Lot 283563 1
Bedinvetmab 1
Butorphaol 1
Frunevetmab 1
Senvelgo Velagliflozin Oral Solution 1
Isoflurane 1
Carprofen 1
Maropitant Citrate 1
Omeprazole 1
Ampicillin 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hypercalcaemic condition (#2242 of 2,481 by report volume); death-coded 29.4%. PlainBreed reaction plate · report volume stamp 17 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →