Reaction profile

The FDA adverse-event record for hydronephrosis

Name: Hydronephrosis - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

17 FDA reports name hydronephrosis, a lower-volume reaction in the CVM extract (VeDDRA 2066). Plate stamps and neighbourhood peers follow.

#2241 of 2,481
by report volume (all reactions): 17
reports citing this reaction: 29.4%
death-coded share: Dog
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hydronephrosis has 17 reports now versus 16 in that prior snapshot: 1 more (6.3%).

Report change: +1
Death-coded reports: +0
Death-coded share: −1.8 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hydronephrosis changes

FDA AER · VeDDRA plate

Code 2066 VOL-TRACE

VOL-TRACE · DEATH-HOT · BOTTOM-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-TRACE 17 reports
DEATH-HOT 29.4%
BOTTOM-DECILE #2241/2481
PHOTO-FINISH Anoestrus
SPECIES-DOG Dog · 11
DRUG-LEAD Buprenorphine · 3
DESK-WIDE 12 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Anoestrus (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Hydronephrosis

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around Hydronephrosis

Hydronephrosis: high death-coded share in the FDA AER plate

Signature read: 17 reports place Hydronephrosis in the lower third of FDA AER volume (#2241 of 2,481). Report volume is lower-third scale: 17 named reports in the openFDA extract. Death-coded share is upper-third: 5 of 17 reports (29.4% of named reports). Nearest volume peer: Anoestrus (±0 reports). Lead species Dog (11). Lead co-reported drug Buprenorphine (3).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 11

Cat 6

Breeds Most Affected

Domestic Shorthair 3

Retriever - Labrador 3

Chihuahua 2

Boxer (German Boxer) 1

Crossbred Canine/dog 1

Beagle 1

Retriever - Golden 1

Retriever - Flat-coated 1

Domestic Mediumhair 1

Siamese 1

Associated Drugs

Buprenorphine 3

Milbemycin Oxime + Spinosad 3

Afoxolaner 3

Fluralaner Chew Tablets 2

Fluid Therapy 2

Cefovecin 1

Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate) 1

Prednisone 1

Oclacitinib Maleate 1

Prednisolone; Trimeprazine Tartrate 1

Robenacoxib 1

Diazepam 1

Bupivacaine 1

Suture 1

Canine Infl H3N8 Kv 1

Canine Infl H3N2 Kv 1

Rabies In Hhh Adj Pfizer Kv 1

Grapiprant 1

Gabapentin 1

Tramadol 1

What to do with this reaction

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hydronephrosis (#2241 of 2,481 by report volume); death-coded 29.4%. PlainBreed reaction plate · report volume stamp 17 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →