Reaction profile

The FDA adverse-event record for hydronephrosis

14 FDA adverse-event reports reference hydronephrosis (VeDDRA 2066). See the species, breeds, and drugs most associated with it below.

14
reports citing this reaction
35.7%
death-coded share
Dog
most-affected species
Buprenorphine
most-associated drug
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14
Total Reports
5
Deaths
35.7%
Death Rate

Species Most Affected

Dog 9
Cat 5

Breeds Most Affected

Domestic Shorthair 3
Chihuahua 2
Retriever - Labrador 2
Boxer (German Boxer) 1
Crossbred Canine/dog 1
Beagle 1
Retriever - Golden 1
Retriever - Flat-coated 1
Domestic Mediumhair 1
Siamese 1

Associated Drugs

Buprenorphine 3
Milbemycin Oxime + Spinosad 3
Afoxolaner 3
Fluralaner Chew Tablets 2
Fluid Therapy 2
Cefovecin 1
Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate) 1
Prednisone 1
Oclacitinib Maleate 1
Prednisolone; Trimeprazine Tartrate 1
Robenacoxib 1
Diazepam 1
Bupivacaine 1
Suture 1
Canine Infl H3N8 Kv 1
Canine Infl H3N2 Kv 1
Rabies In Hhh Adj Pfizer Kv 1
Grapiprant 1
Gabapentin 1
Tramadol 1

Hydronephrosis Reaction Insights

14 reports name Hydronephrosis; 5 recorded a death outcome (35.7% of reported events, not a population-level mortality rate). VeDDRA code: 2066.

By species: Dog (9 reports), Cat (5 reports). By breed: Domestic Shorthair (3), Chihuahua (2), Retriever - Labrador (2).

Most co-reported drugs: Buprenorphine (3 reports), Milbemycin Oxime + Spinosad (3 reports), Afoxolaner (3 reports), Fluralaner Chew Tablets (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.