Reaction profile

The FDA adverse-event record for hepatic fibrosis

49 FDA reports name hepatic fibrosis, a lower-volume reaction in the CVM extract (VeDDRA 488). Plate stamps and neighbourhood peers follow.

#1743 of 2,481
by report volume (all reactions)
49
reports citing this reaction
73.5%
death-coded share
Dog
most-affected species
Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hepatic fibrosis has 49 reports now versus 48 in that prior snapshot: 1 more (2.1%).

Report change
+1
Death-coded reports
+0
Death-coded share
−1.5 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hepatic fibrosis changes

FDA AER · VeDDRA plate

Code 488 VOL-TRACE

VOL-TRACE · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 49 reports
  • DEATH-HOT 73.5%
  • MID-PACK #1743/2481
  • PHOTO-FINISH Entropion
  • SPECIES-DOG Dog · 40
  • DRUG-LEAD Milbemycin Oxime… · 9
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Entropion (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Hepatic fibrosis

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Entropion · near49Hepatic fibrosis · this reac…49INEFFECTIVE, STRONGYL… · near49Nerve damage NOS · near49Pinnal ulcer · near49Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Hepatic fibrosis

Hepatic fibrosis: high death-coded share in the FDA AER plate

Signature read: Hepatic fibrosis's 73.5% death-coded share is among the highest in the openFDA reaction corpus. Report volume is lower-third scale: 49 named reports in the openFDA extract. Death-coded share is upper-third: 36 of 49 reports (73.5% of named reports). Nearest volume peer: Entropion (±0 reports). Lead species Dog (40). Lead co-reported drug Milbemycin Oxime + Spinosad (9).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 40
Cat 4
Horse 3
Chicken 1
Other Reptiles 1

Breeds Most Affected

Retriever - Labrador 10
Dachshund (unspecified) 3
Domestic Shorthair 3
Spitz - German Pomeranian 3
Corgi - Welsh Cardigan 2
Terrier - West Highland White 2
Deutsche Dogge, Great Dane 1
Chicken (unknown) 1
Other Reptiles (other) 1
Collie - Rough-haired 1

Associated Drugs

Milbemycin Oxime + Spinosad 9
Carprofen 8
Maropitant Citrate 8
Buprenorphine 7
Gabapentin 7
Ursodiol 5
Fluralaner Chew Tablets 5
Spinosad 4
Ivermectin 4
Sucralfate 4
Famotidine 3
Amoxicillin + Clavulanic Acid 3
Metronidazole 3
Enrofloxacin 3
Dexamethasone 2
Deracoxib 2
Sam-E, Silybin, Vitamin E, Zinc 2
Ondansetron Hcl 2
Acepromazine Maleate 2
Glucosamine + Chondroitin 2

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hepatic fibrosis (#1743 of 2,481 by report volume); death-coded 73.5%. PlainBreed reaction plate · death-coded share stamp 73.5% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →