Reaction profile

The FDA adverse-event record for hepatic encephalopathy

40 FDA reports name hepatic encephalopathy, a lower-volume reaction in the CVM extract (VeDDRA 486). Plate stamps and neighbourhood peers follow.

#1846 of 2,481
by report volume (all reactions)
40
reports citing this reaction
52.5%
death-coded share
Dog
most-affected species
Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hepatic encephalopathy has 40 reports now versus 40 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hepatic encephalopathy changes

FDA AER · VeDDRA plate

Code 486 VOL-TRACE

VOL-TRACE · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 40 reports
  • DEATH-HOT 52.5%
  • MID-PACK #1846/2481
  • PHOTO-FINISH Acute (interstitial)…
  • SPECIES-DOG Dog · 32
  • DRUG-LEAD Pyrantel Pamoate;… · 7
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Acute (interstitial) pneumonia/pleuropneumonia (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Hepatic encephalopathy

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Acute (interstitial)… · near40Anxious state of mind · near40Direct Coombs test, p… · near40Endocrine neoplasm · near40Hepatic encephalopathy · thi…40Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Hepatic encephalopathy

Hepatic encephalopathy: high death-coded share in the FDA AER plate

Signature read: Hepatic encephalopathy's 52.5% death-coded share is among the highest in the openFDA reaction corpus. Report volume is lower-third scale: 40 named reports in the openFDA extract. Death-coded share is upper-third: 21 of 40 reports (52.5% of named reports). Nearest volume peer: Acute (interstitial) pneumonia/pleuropneumonia (±0 reports). Lead species Dog (32). Lead co-reported drug Pyrantel Pamoate;Sarolaner (7).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 32
Cat 6
Cattle 1
Goat 1

Breeds Most Affected

Terrier - Yorkshire 4
Maltese 4
Terrier - Boston 3
Pit Bull 2
Domestic Shorthair 2
Collie - Border 2
Siamese 2
Pug 2
Brittany 1
Spaniel - Springer (unspecified) 1

Associated Drugs

Pyrantel Pamoate;Sarolaner 7
Carprofen 6
Maropitant Citrate 5
Trilostane 5
Milbemycin Oxime + Spinosad 4
Doxycycline 4
Gabapentin 4
Ketamine 3
Butorphanol 3
Imidacloprid + Moxidectin 3
Thiamazole 3
Grapiprant 3
Ursodiol 3
Neomycin/Polymyxin B Sulfates/Dexamethasone Ophthalmic Suspension 3
Insulin 3
Ivermectin 2
Cefovecin 2
Diazepam 2
Isoflurane 2
Metronidazole 2

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hepatic encephalopathy (#1846 of 2,481 by report volume); death-coded 52.5%. PlainBreed reaction plate · death-coded share stamp 52.5% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →