Reaction profile

The FDA adverse-event record for hepatic cirrhosis

Name: Hepatic cirrhosis - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

23 FDA reports name hepatic cirrhosis, a lower-volume reaction in the CVM extract (VeDDRA 489). Plate stamps and neighbourhood peers follow.

#2109 of 2,481
by report volume (all reactions): 23
reports citing this reaction: 65.2%
death-coded share: Dog
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hepatic cirrhosis has 23 reports now versus 23 in that prior snapshot: 0 the same number of (0.0%).

Report change: +0
Death-coded reports: +0
Death-coded share: −0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hepatic cirrhosis changes

FDA AER · VeDDRA plate

Code 489 VOL-TRACE

VOL-TRACE · DEATH-HOT · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-TRACE 23 reports
DEATH-HOT 65.2%
LOWER-Q #2109/2481
PHOTO-FINISH Anal oedema
SPECIES-DOG Dog · 23
DRUG-LEAD Carprofen · 5
DESK-WIDE 15 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Anal oedema (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Hepatic cirrhosis

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around Hepatic cirrhosis

Hepatic cirrhosis: high death-coded share in the FDA AER plate

Signature read: Hepatic cirrhosis's 65.2% death-coded share is among the highest in the openFDA reaction corpus. Report volume is lower-third scale: 23 named reports in the openFDA extract. Death-coded share is upper-third: 15 of 23 reports (65.2% of named reports). Nearest volume peer: Anal oedema (±0 reports). Lead species Dog (23). Lead co-reported drug Carprofen (5).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 23

Breeds Most Affected

Retriever - Labrador 9

Terrier - Fox Wire 1

Terrier - Scottish 1

Spaniel (unspecified) 1

Hound - Basset 1

Shepherd Dog - German 1

Terrier - West Highland White 1

Terrier - Jack Russell 1

Brittany 1

Beagle 1

Associated Drugs

Carprofen 5

Maropitant Citrate 4

Afoxolaner 4

Sam-E, Silybin, Vitamin E, Zinc 3

Oclacitinib Maleate 3

Prescription Diet (Unspecified) 2

Enrofloxacin 2

Fluralaner Chew Tablets 2

Doxycycline 2

Ivermectin + Pyrantel As Pamoate Salt 2

Tramadol 2

Glycosaminoglycan Polysulfate 1

Trilostane 1

Milbemycin Oxime + Spinosad 1

Spinosad 1

Dirlotapide 1

Levothyroxine Sodium 1

Hetastarch 1

Colchicine 1

Misoprostol 1

What to do with this reaction

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hepatic cirrhosis (#2109 of 2,481 by report volume); death-coded 65.2%. PlainBreed reaction plate · death-coded share stamp 65.2% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →