Reaction profile

The FDA adverse-event record for gut pain

11 FDA adverse-event reports reference gut pain (VeDDRA 1503). See the species, breeds, and drugs most associated with it below.

11
reports citing this reaction
27.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
11
Total Reports
3
Deaths
27.3%
Death Rate

Species Most Affected

Dog 9
Chicken 1
Cat 1

Breeds Most Affected

Poodle - Toy 2
Poodle - Standard 1
Chicken (unknown) 1
Retriever - Labrador 1
Spaniel - King Charles Cavalier 1
Shih Tzu 1
Terrier - Yorkshire 1
Chihuahua 1
Shepherd Dog - Australian 1
Cat (other) 1

Associated Drugs

Milbemycin Oxime + Spinosad 3
Pyrantel Pamoate;Sarolaner 2
Desoxycorticosterone Pivalate 1
Prednisone 1
Amprolium 20% Water Soluble Powder 1
Afoxolaner 2.27% Chewable Tablet (28.3 Mg) 1
Oclacitinib Maleate 1
Fluralaner Chew Tablets 1
Febantel + Praziquantel + Pyrantel Pamoate 1
Carprofen 1
Atipamezole Hydrochloride 1
Dexmedetomidine Hydrochloride 1
Gabapentin 1
Isoflurane 1
Ketamine 1
Butorphanol 1
Toceranib Phosphate 1

Gut pain Reaction Insights

11 reports name Gut pain; 3 recorded a death outcome (27.3% of reported events, not a population-level mortality rate). VeDDRA code: 1503.

By species: Dog (9 reports), Chicken (1 reports), Cat (1 reports). By breed: Poodle - Toy (2), Poodle - Standard (1), Chicken (unknown) (1).

Most co-reported drugs: Milbemycin Oxime + Spinosad (3 reports), Pyrantel Pamoate;Sarolaner (2 reports), Desoxycorticosterone Pivalate (1 reports), Prednisone (1 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.