Reaction profile

The FDA adverse-event record for flehmen response

17 FDA adverse-event reports reference flehmen response (VeDDRA 2532). See the species, breeds, and drugs most associated with it below.

17
reports citing this reaction
5.9%
death-coded share
Horse
most-affected species
Clodronate Disodium
most-associated drug
Verify with FDA CVM →
17
Total Reports
1
Deaths
5.9%
Death Rate

Species Most Affected

Horse 16
Dog 1

Breeds Most Affected

Warmblood (unspecified) 3
Quarter Horse 3
Thoroughbred 3
Horse (unknown) 3
Hanovarian 1
Crossbred Canine/dog 1
Paint 1
Horse (other) 1
Morgan 1

Associated Drugs

Clodronate Disodium 7
Gentamicin Sulfate 2
Ceftiofur Crystalline Free Acid 2
Enrofloxacin 1
Phenylbutazone 1
Firocoxib 1
Flunixin 1
Fluralaner Chew Tablets 1
N-Butylscopolaminium Bromide 1
Equine Potomavac - 2639.00 1
Flunixin Meglumine 1
Polysulfated Glycosaminoglycan 1
Tulathromycin 1
Pentosan Polysulfate Sodium 1

Flehmen response Reaction Insights

17 reports name Flehmen response; 1 recorded a death outcome (5.9% of reported events, not a population-level mortality rate). VeDDRA code: 2532.

By species: Horse (16 reports), Dog (1 reports). By breed: Warmblood (unspecified) (3), Quarter Horse (3), Thoroughbred (3).

Most co-reported drugs: Clodronate Disodium (7 reports), Gentamicin Sulfate (2 reports), Ceftiofur Crystalline Free Acid (2 reports), Enrofloxacin (1 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.