Reaction profile

The FDA adverse-event record for flaccid paralysis

44 FDA adverse-event reports reference flaccid paralysis (VeDDRA 695). See the species, breeds, and drugs most associated with it below.

44
reports citing this reaction
31.8%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
44
Total Reports
14
Deaths
31.8%
Death Rate

Species Most Affected

Dog 31
Cat 10
Horse 2
Turkey 1

Breeds Most Affected

Domestic Shorthair 7
Retriever - Labrador 4
Crossbred Canine/dog 4
Pit Bull 3
Quarter Horse 2
Shepherd Dog - German 2
Collie - Border 2
Mixed (Dog) 2
Pekingese 1
Turkey (unknown) 1

Associated Drugs

Milbemycin Oxime + Spinosad 5
Spinosad 4
Carprofen 4
Bedinvetmab 4
Ivermectin 3
Afoxolaner 3
Fluralaner 13.64% 12-Week Chew 3
Emodepside + Praziquantel 2
Cefovecin 2
Moxidectin 2
Imidacloprid + Moxidectin 2
Fluralaner Chew Tablets 2
Frunevetmab 2
Rabies 1
Fvrcp 1
Feline Leukemia Vaccine 1
Monensin Sodium 1
Sulfonamide (Unknown) 1
Ivermectin/Pyrantel Pamoate Chewable 136Mcg/326Mg 1
Melarsomine Dihydrochloride Injection 1

Flaccid paralysis Reaction Insights

44 reports name Flaccid paralysis; 14 recorded a death outcome (31.8% of reported events, not a population-level mortality rate). VeDDRA code: 695.

By species: Dog (31 reports), Cat (10 reports), Horse (2 reports). By breed: Domestic Shorthair (7), Retriever - Labrador (4), Crossbred Canine/dog (4).

Most co-reported drugs: Milbemycin Oxime + Spinosad (5 reports), Spinosad (4 reports), Carprofen (4 reports), Bedinvetmab (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.