Reaction profile

The FDA adverse-event record for fit

Name: Fit - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

18 FDA reports name fit, a lower-volume reaction in the CVM extract (VeDDRA 643). Plate stamps and neighbourhood peers follow.

#2208 of 2,481
by report volume (all reactions): 18
reports citing this reaction: 38.9%
death-coded share: Dog
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Fit has 18 reports now versus 18 in that prior snapshot: 0 the same number of (0.0%).

Report change: +0
Death-coded reports: +0
Death-coded share: −0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Fit changes

FDA AER · VeDDRA plate

Code 643 VOL-TRACE

VOL-TRACE · DEATH-HOT · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-TRACE 18 reports
DEATH-HOT 38.9%
LOWER-Q #2208/2481
PHOTO-FINISH ALBUMIN/GLOBULIN RATI…
SPECIES-DOG Dog · 15
DRUG-LEAD Milbemycin Oxime… · 2
DESK-WIDE 15 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: ALBUMIN/GLOBULIN RATIO HI, BLD (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Fit

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around Fit

Fit: high death-coded share in the FDA AER plate

Signature read: 18 reports place Fit in the lower third of FDA AER volume (#2208 of 2,481). Report volume is lower-third scale: 18 named reports in the openFDA extract. Death-coded share is upper-third: 7 of 18 reports (38.9% of named reports). Nearest volume peer: ALBUMIN/GLOBULIN RATIO HI, BLD (±0 reports). Lead species Dog (15). Lead co-reported drug Milbemycin Oxime + Spinosad (2).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 15

Horse 1

Alpaca 1

Cat 1

Breeds Most Affected

Dog (unknown) 2

Shepherd Dog - Australian 2

Shih Tzu 2

Quarter Horse 1

Berger de Brie (Briard) - Briard 1

Maltese 1

Terrier (unspecified) 1

Greyhound 1

Pinscher - Miniature 1

Collie - Border 1

Associated Drugs

Milbemycin Oxime + Spinosad 2

Fluralaner 13.64% 12-Week Chew 2

Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 2

Sedative (Unknown) 2

Prednisone 2

Gabapentin 2

Maropitant Citrate 2

Buprenorphine 2

Xylazine 1

Estriol Tablets 1

Afoxolaner 2.27% Chewable Tablet (68 Mg) 1

Afoxolaner 2.27% Chewable Tablet (28.3 Mg) 1

Spinosad 1

Flea Product (Unknown) 1

Afoxolaner 136 Mg Chewable Tablets 1

Oclacitinib Maleate 1

Sarolaner 1

Butorphanol Tartrate 1

Tobramycin Ophthalmic 1

Pyrantel Pamoate;Sarolaner 1

What to do with this reaction

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Fit (#2208 of 2,481 by report volume); death-coded 38.9%. PlainBreed reaction plate · report volume stamp 18 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →