Reaction profile

The FDA adverse-event record for fit

17 FDA adverse-event reports reference fit (VeDDRA 643). See the species, breeds, and drugs most associated with it below.

17
reports citing this reaction
41.2%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
17
Total Reports
7
Deaths
41.2%
Death Rate

Species Most Affected

Dog 14
Horse 1
Alpaca 1
Cat 1

Breeds Most Affected

Dog (unknown) 2
Shih Tzu 2
Quarter Horse 1
Berger de Brie (Briard) - Briard 1
Maltese 1
Terrier (unspecified) 1
Greyhound 1
Pinscher - Miniature 1
Collie - Border 1
Bichon Frise 1

Associated Drugs

Milbemycin Oxime + Spinosad 2
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 2
Maropitant Citrate 2
Sedative (Unknown) 2
Prednisone 2
Gabapentin 2
Buprenorphine 2
Xylazine 1
Estriol Tablets 1
Afoxolaner 2.27% Chewable Tablet (68 Mg) 1
Afoxolaner 2.27% Chewable Tablet (28.3 Mg) 1
Spinosad 1
Flea Product (Unknown) 1
Afoxolaner 136 Mg Chewable Tablets 1
Oclacitinib Maleate 1
Sarolaner 1
Butorphanol Tartrate 1
Fluralaner 13.64% 12-Week Chew 1
Tobramycin Ophthalmic 1
Pyrantel Pamoate;Sarolaner 1

Fit Reaction Insights

17 reports name Fit; 7 recorded a death outcome (41.2% of reported events, not a population-level mortality rate). VeDDRA code: 643.

By species: Dog (14 reports), Horse (1 reports), Alpaca (1 reports). By breed: Dog (unknown) (2), Shih Tzu (2), Quarter Horse (1).

Most co-reported drugs: Milbemycin Oxime + Spinosad (2 reports), Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (2 reports), Maropitant Citrate (2 reports), Sedative (Unknown) (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.