Reaction profile

The FDA adverse-event record for endocrine neoplasm

40 FDA adverse-event reports reference endocrine neoplasm (VeDDRA 386). See the species, breeds, and drugs most associated with it below.

40
reports citing this reaction
47.5%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
40
Total Reports
19
Deaths
47.5%
Death Rate

Species Most Affected

Dog 36
Cat 2
Horse 1
Ferret 1

Breeds Most Affected

Crossbred Canine/dog 4
Retriever - Labrador 4
Dog (unknown) 3
Shepherd Dog - Australian 2
Collie - Border 2
Boxer (German Boxer) 2
Shih Tzu 2
Maltese 2
Shiba Inu 1
Beagle 1

Associated Drugs

Milbemycin Oxime + Spinosad 7
Trilostane 6
Carprofen 4
Afoxolaner 3
Fluralaner Chew Tablets 3
Polysulfated Glycosaminoglycan 2
Levothyroxine 2
Spinosad 2
Antibiotic (Unknown) 2
Oclacitinib Maleate 2
Milbemycin Oxime 2
Deracoxib 2
Cyclosporine 2
Grapiprant 2
Rabies Vaccination 1
Diphenhydramine 1
Triamcinolone 1
Cyclosporine A 1
Enalapril 1
Glycosaminoglycan Polysulfate 1

Endocrine neoplasm Reaction Insights

40 reports name Endocrine neoplasm; 19 recorded a death outcome (47.5% of reported events, not a population-level mortality rate). VeDDRA code: 386.

By species: Dog (36 reports), Cat (2 reports), Horse (1 reports). By breed: Crossbred Canine/dog (4), Retriever - Labrador (4), Dog (unknown) (3).

Most co-reported drugs: Milbemycin Oxime + Spinosad (7 reports), Trilostane (6 reports), Carprofen (4 reports), Afoxolaner (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.