Reaction profile

The FDA adverse-event record for encephalopathy nos

34 FDA reports name encephalopathy nos, a lower-volume reaction in the CVM extract (VeDDRA 666). Plate stamps and neighbourhood peers follow.

#1928 of 2,481
by report volume (all reactions)
34
reports citing this reaction
64.7%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Encephalopathy NOS has 34 reports now versus 33 in that prior snapshot: 1 more (3.0%).

Report change
+1
Death-coded reports
+1
Death-coded share
+1.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Encephalopathy NOS changes

FDA AER · VeDDRA plate

Code 666 VOL-TRACE

VOL-TRACE · DEATH-HOT · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 34 reports
  • DEATH-HOT 64.7%
  • LOWER-Q #1928/2481
  • PHOTO-FINISH Attractiveness to mal…
  • SPECIES-DOG Dog · 28
  • DRUG-LEAD Carprofen · 7
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Attractiveness to males (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Encephalopathy NOS

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Attractiveness to mal… · near34Encephalopathy NOS · this re…34Eyelid mass NOS · near34PR-THYMUS, LESION(S) · near34Product tampering · near34Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Encephalopathy NOS

Encephalopathy NOS: high death-coded share in the FDA AER plate

Signature read: Encephalopathy NOS's 64.7% death-coded share is among the highest in the openFDA reaction corpus. Report volume is lower-third scale: 34 named reports in the openFDA extract. Death-coded share is upper-third: 22 of 34 reports (64.7% of named reports). Nearest volume peer: Attractiveness to males (±0 reports). Lead species Dog (28). Lead co-reported drug Carprofen (7).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 28
Cat 2
Guinea Pig 1
Cattle 1
Horse 1
Pig 1

Breeds Most Affected

Retriever - Labrador 5
Maltese 3
Crossbred Canine/dog 3
Poodle - Miniature 2
Domestic Shorthair 2
Chihuahua 2
Unknown 1
Schnauzer (unspecified) 1
Terrier - Yorkshire 1
Boxer (German Boxer) 1

Associated Drugs

Carprofen 7
Spinosad 3
Milbemycin Oxime + Spinosad 3
Pimobendan 2
Afoxolaner 2
Fluralaner 13.64% 12-Week Chew 2
Levothyroxine 2
Sarolaner 2
Bedinvetmab 2
Deracoxib 1
Selamectin 1
Cefpodoxime Proxetil 1
Imidacloprid + Moxidectin 1
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 1
Bordetella Bronchiseptica, Strain 78-9159, Kb 1
Dexamethasone 1
Famotidine 1
Meloxicam 1
Afoxolaner 28.3 Mg Chewable Tablets 1
Milbemycin Oxime + Praziquantel 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Encephalopathy NOS (#1928 of 2,481 by report volume); death-coded 64.7%. PlainBreed reaction plate · death-coded share stamp 64.7% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →