Reaction profile

The FDA adverse-event record for discoloured teeth

18 FDA reports name discoloured teeth, a lower-volume reaction in the CVM extract (VeDDRA 282). Plate stamps and neighbourhood peers follow.

#2205 of 2,481
by report volume (all reactions)
18
reports citing this reaction
0.0%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Discoloured teeth has 18 reports now versus 18 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Discoloured teeth changes

FDA AER · VeDDRA plate

Code 282 VOL-TRACE

VOL-TRACE · DEATH-RARE · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 18 reports
  • DEATH-RARE 0.0%
  • LOWER-Q #2205/2481
  • PHOTO-FINISH ALBUMIN/GLOBULIN RATI…
  • SPECIES-DOG Dog · 16
  • DRUG-LEAD Spinosad · 2
  • DESK-WIDE 13 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: ALBUMIN/GLOBULIN RATIO HI, BLD (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Discoloured teeth

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348ALBUMIN/GLOBULIN RATI… · near18Application site skin… · near18Bone marrow hypoplasia · near18Cognitive disturbance · near18Discoloured teeth · this rea…18Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Discoloured teeth

Discoloured teeth: low death-coded share in the FDA AER plate

Signature read: Discoloured teeth's 0.0% death-coded share is among the lowest in the openFDA reaction corpus. Report volume is lower-third scale: 18 named reports in the openFDA extract. Death-coded share is lower-third: 0 of 18 reports (0.0% of named reports). Nearest volume peer: ALBUMIN/GLOBULIN RATIO HI, BLD (±0 reports). Lead species Dog (16). Lead co-reported drug Spinosad (2).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 16
Human 1
Cat 1

Breeds Most Affected

Maltese 2
Crossbred Canine/dog 2
Shepherd Dog - German 2
Retriever - Labrador 2
Terrier - Yorkshire 2
Poodle (unspecified) 1
Unknown 1
Shepherd Dog - Anatolian 1
Domestic Shorthair 1
Schnauzer - Miniature 1

Associated Drugs

Spinosad 2
Milbemycin Oxime + Spinosad 2
Milbemycin Oxime + Praziquantel 2
Moxidectin 1
Activated Attapulgite; Bismuth Subcarbonate; Kanamycin 1
Fluralaner Chew Tablets 1
Pyrantel Pamoate (Pyrantel Embonate) 1
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 1
Canine Coronavirus, Strain Nl-18, Ms-P40 Lot #1, 9-29-82 1
Carprofen 1
Tramadol 1
Oravet Plaque Prevention Gel 1
Eprinomectin 1
Ivermectin + Pyrantel As Pamoate Salt 1
Cyphenothrin + Fipronil + S-Methoprene 1
Telmisartan 1
Levothyroxine Sodium, Usp 1
Afoxolaner 1
Bordetella Bronchiseptica, Boehringer Ingelheim Strain,Canine Adenovirus Type 2 Virus - Norden Strain,Canine Parainfluenza, 91880 Strain 1
Phenobarbital 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Discoloured teeth (#2205 of 2,481 by report volume); death-coded 0.0%. PlainBreed reaction plate · death-coded share stamp 0.0% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →