Reaction profile

The FDA adverse-event record for discoloured teeth

18 FDA adverse-event reports reference discoloured teeth (VeDDRA 282). See the species, breeds, and drugs most associated with it below.

18
reports citing this reaction
0.0%
death-coded share
Dog
most-affected species
Spinosad
most-associated drug
Verify with FDA CVM →
18
Total Reports
0
Deaths
0.0%
Death Rate

Species Most Affected

Dog 16
Human 1
Cat 1

Breeds Most Affected

Maltese 2
Shepherd Dog - German 2
Crossbred Canine/dog 2
Retriever - Labrador 2
Terrier - Yorkshire 2
Poodle (unspecified) 1
Unknown 1
Shepherd Dog - Anatolian 1
Domestic Shorthair 1
Schnauzer - Miniature 1

Associated Drugs

Spinosad 2
Milbemycin Oxime + Spinosad 2
Milbemycin Oxime + Praziquantel 2
Moxidectin 1
Activated Attapulgite; Bismuth Subcarbonate; Kanamycin 1
Fluralaner Chew Tablets 1
Pyrantel Pamoate (Pyrantel Embonate) 1
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 1
Canine Coronavirus, Strain Nl-18, Ms-P40 Lot #1, 9-29-82 1
Carprofen 1
Tramadol 1
Oravet Plaque Prevention Gel 1
Eprinomectin 1
Ivermectin + Pyrantel As Pamoate Salt 1
Cyphenothrin + Fipronil + S-Methoprene 1
Telmisartan 1
Levothyroxine Sodium, Usp 1
Afoxolaner 1
Bordetella Bronchiseptica, Boehringer Ingelheim Strain,Canine Adenovirus Type 2 Virus - Norden Strain,Canine Parainfluenza, 91880 Strain 1
Phenobarbital 1

Discoloured teeth Reaction Insights

18 reports name Discoloured teeth; 0 recorded a death outcome (0.0% of reported events, not a population-level mortality rate). VeDDRA code: 282.

By species: Dog (16 reports), Human (1 reports), Cat (1 reports). By breed: Maltese (2), Shepherd Dog - German (2), Crossbred Canine/dog (2).

Most co-reported drugs: Spinosad (2 reports), Milbemycin Oxime + Spinosad (2 reports), Milbemycin Oxime + Praziquantel (2 reports), Moxidectin (1 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.