Reaction profile

The FDA adverse-event record for direct coombs test, positive

Name: Direct Coombs test, positive - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

40 FDA reports name direct coombs test, positive, a lower-volume reaction in the CVM extract (VeDDRA 2697). Plate stamps and neighbourhood peers follow.

#1844 of 2,481
by report volume (all reactions): 40
reports citing this reaction: 37.5%
death-coded share: Dog
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Direct Coombs test, positive has 40 reports now versus 38 in that prior snapshot: 2 more (5.3%).

Report change: +2
Death-coded reports: +0
Death-coded share: −2.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Direct Coombs test, positive changes

FDA AER · VeDDRA plate

Code 2697 VOL-TRACE

VOL-TRACE · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-TRACE 40 reports
DEATH-HOT 37.5%
MID-PACK #1844/2481
PHOTO-FINISH Acute (interstitial)…
SPECIES-DOG Dog · 39
DRUG-LEAD Moxidectin · 8
DESK-WIDE 20 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Acute (interstitial) pneumonia/pleuropneumonia (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Direct Coombs test, positive

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around Direct Coombs test, positive

Direct Coombs test, positive: high death-coded share in the FDA AER plate

Signature read: Direct Coombs test, positive's 37.5% death-coded share is among the highest in the openFDA reaction corpus. Report volume is lower-third scale: 40 named reports in the openFDA extract. Death-coded share is upper-third: 15 of 40 reports (37.5% of named reports). Nearest volume peer: Acute (interstitial) pneumonia/pleuropneumonia (±0 reports). Lead species Dog (39). Lead co-reported drug Moxidectin (8).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 39

Cat 1

Breeds Most Affected

Crossbred Canine/dog 6

Spaniel (unspecified) 3

Retriever - Labrador 3

Sheepdog - Shetland 2

Shih Tzu 2

Ridgeback - Rhodesian 2

Boxer (German Boxer) 1

Schnauzer (unspecified) 1

Bichon Frise 1

Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)) 1

Associated Drugs

Moxidectin 8

Maropitant Citrate 8

Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 8

Prednisone 6

Bedinvetmab 6

Doxycycline 5

Milbemycin Oxime + Spinosad 3

Oclacitinib Maleate 3

Cefovecin 3

Cyclosporine 3

Gabapentin 3

Pyrantel Pamoate;Sarolaner 3

Afoxolaner 3

Pyrantel Pamoate 3

Enrofloxacin 2

Cefpodoxime 2

Ondansetron Hcl 2

Sarolaner 2

Dexamethasone 2

Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 2

What to do with this reaction

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Direct Coombs test, positive (#1844 of 2,481 by report volume); death-coded 37.5%. PlainBreed reaction plate · death-coded share stamp 37.5% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →