Reaction profile
The FDA adverse-event record for cushings disease - adrenal dependent
11 FDA reports name cushings disease - adrenal dependent, a lower-volume reaction in the CVM extract (VeDDRA 382). Plate stamps and neighbourhood peers follow.
- #2411 of 2,481
- by report volume (all reactions)
- 11
- reports citing this reaction
- 27.3%
- death-coded share
- Dog
- most-affected species
Release-over-release change
What changed in the latest FDA data snapshot
PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Cushings disease - adrenal dependent has 11 reports now versus 10 in that prior snapshot: 1 more (10.0%).
- Report change
- +1
- Death-coded reports
- +0
- Death-coded share
- −2.7 pts
This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.
Subscribe to Cushings disease - adrenal dependent changesFDA AER · VeDDRA plate
Code 382 VOL-TRACE
VOL-TRACE · DEATH-HOT · BOTTOM-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL
- VOL-TRACE 11 reports
- DEATH-HOT 27.3%
- BOTTOM-DECILE #2411/2481
- PHOTO-FINISH ABNORMAL PANCREATIC S…
- SPECIES-DOG Dog · 11
- DRUG-LEAD Trilostane · 3
- DESK-WIDE 11 breeds
- BOOK-FULL 8/8 fields
Nearest volume peer: ABNORMAL PANCREATIC SPECIFIC LIPASE (PLI) (±0 reports)
Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.
Lower-volume neighbourhood around Cushings disease - adrenal dependent
Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.
Cushings disease - adrenal dependent: high death-coded share in the FDA AER plate
Signature read: 11 reports place Cushings disease - adrenal dependent in the lower third of FDA AER volume (#2411 of 2,481). Report volume is lower-third scale: 11 named reports in the openFDA extract. Death-coded share is upper-third: 3 of 11 reports (27.3% of named reports). Nearest volume peer: ABNORMAL PANCREATIC SPECIFIC LIPASE (PLI) (±0 reports). Lead species Dog (11). Lead co-reported drug Trilostane (3).
Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.
Species Most Affected
Breeds Most Affected
Associated Drugs
What to do with this reaction
- Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
- Browse the full reaction directory to compare report counts across reaction types. All reactions
A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.
Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025
Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →