Reaction profile

The FDA adverse-event record for cortisol:creatinine hi, urine

Name: CORTISOL:CREATININE HI, URINE - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

23 FDA reports name cortisol:creatinine hi, urine, a lower-volume reaction in the CVM extract (VeDDRA 99234). Plate stamps and neighbourhood peers follow.

#2106 of 2,481
by report volume (all reactions): 23
reports citing this reaction: 4.3%
death-coded share: Dog
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. CORTISOL:CREATININE HI, URINE has 23 reports now versus 23 in that prior snapshot: 0 the same number of (0.0%).

Report change: +0
Death-coded reports: +0
Death-coded share: +0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to CORTISOL:CREATININE HI, URINE changes

FDA AER · VeDDRA plate

Code 99234 VOL-TRACE

VOL-TRACE · DEATH-LOW · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-TRACE 23 reports
DEATH-LOW 4.3%
LOWER-Q #2106/2481
PHOTO-FINISH Anal oedema
SPECIES-DOG Dog · 23
DRUG-LEAD Trilostane · 12
DESK-WIDE 18 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Anal oedema (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around CORTISOL:CREATININE HI, URINE

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around CORTISOL:CREATININE HI, URINE

CORTISOL:CREATININE HI, URINE: low death-coded share in the FDA AER plate

Signature read: 1 death-coded reports is a thin tail count for CORTISOL:CREATININE HI, URINE in the CVM extract. Report volume is lower-third scale: 23 named reports in the openFDA extract. Death-coded share is lower-third: 1 of 23 reports (4.3% of named reports). Nearest volume peer: Anal oedema (±0 reports). Lead species Dog (23). Lead co-reported drug Trilostane (12).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Trilostane appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 23

Breeds Most Affected

Retriever - Labrador 3

Crossbred Canine/dog 3

Dog (other) 2

Terrier - Boston 1

Poodle (unspecified) 1

Dog (unknown) 1

Terrier (unspecified) 1

Dachshund - Standard Smooth-haired 1

Dachshund - Miniature 1

Terrier - Silky 1

Associated Drugs

Trilostane 12

Oclacitinib Maleate 4

Cyclosporine 3

Glycosaminoglycan Polysulfate 2

Milbemycin Oxime + Spinosad 2

Milbemycin, Lufenuron 1

Carprofen 1

Toceranib Phosphate 1

Prednisone 1

Sucralfate 1

Cimetidine 1

Diphenhydramine Hcl 1

Benazepril Hydrochloride 1

Enalapril 1

Levothyroxine 1

Cefovecin 1

Glucosamine & Chondroitin Sulfate 1

Fish Oil 1

Sam-E, Silybin, Vitamin E, Zinc 1

Tramadol 1

What to do with this reaction

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for CORTISOL:CREATININE HI, URINE (#2106 of 2,481 by report volume); death-coded 4.3%. PlainBreed reaction plate · death-coded report count stamp 1 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →