Reaction profile

The FDA adverse-event record for cholangitis

28 FDA reports name cholangitis, a lower-volume reaction in the CVM extract (VeDDRA 477). Plate stamps and neighbourhood peers follow.

#2022 of 2,481
by report volume (all reactions)
28
reports citing this reaction
35.7%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Cholangitis has 28 reports now versus 28 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Cholangitis changes

FDA AER · VeDDRA plate

Code 477 VOL-TRACE

VOL-TRACE · DEATH-HOT · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 28 reports
  • DEATH-HOT 35.7%
  • LOWER-Q #2022/2481
  • PHOTO-FINISH Absence seizure
  • SPECIES-DOG Dog · 18
  • DRUG-LEAD Maropitant Citrate · 6
  • DESK-WIDE 18 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Absence seizure (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Cholangitis

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Absence seizure · near28Application site brui… · near28BILIRUBIN(DIRECT) HIG… · near28Cholangitis · this reaction28Emphysema NOS (see 'R… · near28Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Cholangitis

Cholangitis: high death-coded share in the FDA AER plate

Signature read: 28 reports place Cholangitis in the lower third of FDA AER volume (#2022 of 2,481). Report volume is lower-third scale: 28 named reports in the openFDA extract. Death-coded share is upper-third: 10 of 28 reports (35.7% of named reports). Nearest volume peer: Absence seizure (±0 reports). Lead species Dog (18). Lead co-reported drug Maropitant Citrate (6).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 18
Cat 9
Cattle 1

Breeds Most Affected

Domestic Shorthair 7
Terrier (unspecified) 3
Retriever - Labrador 3
Poodle - Standard 1
Norwegian Forest 1
Maltese 1
Spaniel - King Charles Cavalier 1
Pug 1
Retriever - Flat-coated 1
Great Pyrenees 1

Associated Drugs

Maropitant Citrate 6
Carprofen 5
Bexagliflozin 4
Milbemycin Oxime + Praziquantel 3
Famotidine 2
Moxidectin 2
Marbofloxacin 2
Amoxicillin 2
Ivermectin + Pyrantel Pamoate + Praziquantel 2
Fipronil + (S)-Methoprene 2
Probiotic (Unknown) 2
Phycocyanin + Glucosamine + Methylsulfonylmethane + Minerals + Essential Fatty Acids 2
Trazodone 2
Itraconazole 2
Frunevetmab 2
Dexmedetomidine 2
Miconazole Nitrate, Polymyxin B Sulfate, Prednisolone Acetate 2
Milbemycin Oxime + Spinosad 1
Robenacoxib 1
Cefpodoxime Proxetil 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Cholangitis (#2022 of 2,481 by report volume); death-coded 35.7%. PlainBreed reaction plate · report volume stamp 28 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →