Reaction profile

The FDA adverse-event record for cholangitis

26 FDA adverse-event reports reference cholangitis (VeDDRA 477). See the species, breeds, and drugs most associated with it below.

26
reports citing this reaction
30.8%
death-coded share
Dog
most-affected species
Maropitant Citrate
most-associated drug
Verify with FDA CVM →
26
Total Reports
8
Deaths
30.8%
Death Rate

Species Most Affected

Dog 16
Cat 9
Cattle 1

Breeds Most Affected

Domestic Shorthair 7
Terrier (unspecified) 3
Poodle - Standard 1
Norwegian Forest 1
Maltese 1
Spaniel - King Charles Cavalier 1
Pug 1
Retriever - Labrador 1
Retriever - Flat-coated 1
Great Pyrenees 1

Associated Drugs

Maropitant Citrate 6
Carprofen 5
Bexagliflozin 4
Milbemycin Oxime + Praziquantel 3
Famotidine 2
Moxidectin 2
Marbofloxacin 2
Amoxicillin 2
Ivermectin + Pyrantel Pamoate + Praziquantel 2
Fipronil + (S)-Methoprene 2
Probiotic (Unknown) 2
Phycocyanin + Glucosamine + Methylsulfonylmethane + Minerals + Essential Fatty Acids 2
Itraconazole 2
Frunevetmab 2
Milbemycin Oxime + Spinosad 1
Robenacoxib 1
Cefpodoxime Proxetil 1
Cefovecin 1
Oclacitinib Maleate 1
Fluralaner Chew Tablets 1

Cholangitis Reaction Insights

26 reports name Cholangitis; 8 recorded a death outcome (30.8% of reported events, not a population-level mortality rate). VeDDRA code: 477.

By species: Dog (16 reports), Cat (9 reports), Cattle (1 reports). By breed: Domestic Shorthair (7), Terrier (unspecified) (3), Poodle - Standard (1).

Most co-reported drugs: Maropitant Citrate (6 reports), Carprofen (5 reports), Bexagliflozin (4 reports), Milbemycin Oxime + Praziquantel (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.