Reaction profile

The FDA adverse-event record for cerebral oedema

35 FDA reports name cerebral oedema, a lower-volume reaction in the CVM extract (VeDDRA 635). Plate stamps and neighbourhood peers follow.

#1918 of 2,481
by report volume (all reactions)
35
reports citing this reaction
77.1%
death-coded share
Dog
most-affected species
Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Cerebral oedema has 35 reports now versus 33 in that prior snapshot: 2 more (6.1%).

Report change
+2
Death-coded reports
+2
Death-coded share
+1.4 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Cerebral oedema changes

FDA AER · VeDDRA plate

Code 635 VOL-TRACE

VOL-TRACE · DEATH-HOT · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 35 reports
  • DEATH-HOT 77.1%
  • LOWER-Q #1918/2481
  • PHOTO-FINISH CARBON DIOXIDE LOW, B…
  • SPECIES-DOG Dog · 26
  • DRUG-LEAD Milbemycin Oxime… · 7
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: CARBON DIOXIDE LOW, BLOOD (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Cerebral oedema

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348CARBON DIOXIDE LOW, B… · near35Cerebral oedema · this react…35Comedo/blackhead · near35Gastric torsion · near35Injection site joint… · near35Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Cerebral oedema

Cerebral oedema: high death-coded share in the FDA AER plate

Signature read: Cerebral oedema's 77.1% death-coded share is among the highest in the openFDA reaction corpus. Report volume is lower-third scale: 35 named reports in the openFDA extract. Death-coded share is upper-third: 27 of 35 reports (77.1% of named reports). Nearest volume peer: CARBON DIOXIDE LOW, BLOOD (±0 reports). Lead species Dog (26). Lead co-reported drug Milbemycin Oxime + Spinosad (7).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 26
Cat 8
Horse 1

Breeds Most Affected

Retriever - Labrador 4
Domestic Shorthair 4
Maltese 3
Domestic Mediumhair 3
Terrier - Yorkshire 2
Shepherd Dog - German 2
Retriever - Golden 2
Cat (unknown) 1
Bichon Frise 1
Spaniel - King Charles Cavalier 1

Associated Drugs

Milbemycin Oxime + Spinosad 7
Buprenorphine 5
Fluralaner Spot-On Solution 4
Prednisone 3
Dexamethasone 3
Carprofen 3
Pyrantel Pamoate;Sarolaner 3
Gabapentin 3
Enrofloxacin 2
Doxycycline 2
Afoxolaner 2
Marbofloxacin 2
Dexmedetomidine 2
Propofol 2
Bedinvetmab 2
Milbemycin/Lufenuron/Pzq Chew 2
Leave On Conditioner 2
Eprinomectin + Esafoxolaner + Praziquantel 2
Cefovecin 1
Dexmedetomidine Hydrochloride 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Cerebral oedema (#1918 of 2,481 by report volume); death-coded 77.1%. PlainBreed reaction plate · death-coded share stamp 77.1% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →