Reaction profile

The FDA adverse-event record for cardiac insufficiency

17 FDA reports name cardiac insufficiency, a lower-volume reaction in the CVM extract (VeDDRA 2160). Plate stamps and neighbourhood peers follow.

#2235 of 2,481
by report volume (all reactions)
17
reports citing this reaction
64.7%
death-coded share
Dog
most-affected species
Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Cardiac insufficiency has 17 reports now versus 17 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Cardiac insufficiency changes

FDA AER · VeDDRA plate

Code 2160 VOL-TRACE

VOL-TRACE · DEATH-HOT · BOTTOM-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 17 reports
  • DEATH-HOT 64.7%
  • BOTTOM-DECILE #2235/2481
  • PHOTO-FINISH Anoestrus
  • SPECIES-DOG Dog · 12
  • DRUG-LEAD Milbemycin Oxime… · 5
  • DESK-WIDE 13 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Anoestrus (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Cardiac insufficiency

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Anoestrus · near17Bone nonunion, medica… · near17Cardiac insufficiency · this…17Cerebral vascular acc… · near17Complications of devi… · near17Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Cardiac insufficiency

Cardiac insufficiency: high death-coded share in the FDA AER plate

Signature read: Cardiac insufficiency's 64.7% death-coded share is among the highest in the openFDA reaction corpus. Report volume is lower-third scale: 17 named reports in the openFDA extract. Death-coded share is upper-third: 11 of 17 reports (64.7% of named reports). Nearest volume peer: Anoestrus (±0 reports). Lead species Dog (12). Lead co-reported drug Milbemycin Oxime + Spinosad (5).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 12
Cat 3
Cattle 1
Rabbit 1

Breeds Most Affected

Shepherd Dog - German 2
Retriever - Golden 2
Chihuahua 2
Cat (other) 2
Holstein-Friesian also known as Holstein 1
Spaniel - Cocker English 1
Beagle 1
Terrier - Boston 1
Himalayan 1
Shih Tzu 1

Associated Drugs

Milbemycin Oxime + Spinosad 5
Prednisone 2
Pimobendan 2
Moxidectin 2
Verdinexor 2
Monensin Sodium 1
Lasalocid 1
Melarsomine Dihydrochloride Injection 1
Probiotic Supplement 1
Trilostane 1
Firocoxib 1
Imidacloprid + Moxidectin 1
Enrofloxacin 1
Phenylpropanolamine 1
Fluralaner Chew Tablets 1
Spinosad 1
Nitenpyram 1
Spinetoram 1
Oclacitinib Maleate 1
Maropitant Citrate 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Cardiac insufficiency (#2235 of 2,481 by report volume); death-coded 64.7%. PlainBreed reaction plate · death-coded share stamp 64.7% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →