Reaction profile

The FDA adverse-event record for buccal irritation

45 FDA adverse-event reports reference buccal irritation (VeDDRA 299). See the species, breeds, and drugs most associated with it below.

45
reports citing this reaction
8.9%
death-coded share
Horse
most-affected species
Ivermectin, Praziquantel
most-associated drug
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45
Total Reports
4
Deaths
8.9%
Death Rate

Species Most Affected

Horse 28
Dog 13
Cat 4

Breeds Most Affected

Horse (unknown) 12
Crossbred Canine/dog 4
Thoroughbred 4
Crossbred Equine/horse 3
Boxer (German Boxer) 3
Domestic (unspecified) 3
Quarter Horse 3
Paso Fino 2
Ridgeback - Rhodesian 1
Mountain Dog - Bernese 1

Associated Drugs

Ivermectin, Praziquantel 20
Hexetidine 2
Deracoxib 2
Ponazuril 2
Ivermectin(1.55%)/Praziquantel(7.75%) Paste 2
Ivermectin + Praziquantel 2
Triamcinolone Acetonide 1
Melarsomine Dihydrochloride 1
Carprofen 1
Ivermectin, Pyrantel Pamoate, Praziquantel 1
Meloxicam 1
Pimobendan 1
Orbifloxacin 1
Cyclosporine 1
Amoxicillin 1
Ivermectin 272Mcg, Pyrantel Pamoate 228Mg, Praziquantel 228Mg 1
Firocoxib 227 Mg Chewable 1
Cholestyramine 1
Isoflurane 1
Propofol 1

Buccal irritation Reaction Insights

45 reports name Buccal irritation; 4 recorded a death outcome (8.9% of reported events, not a population-level mortality rate). VeDDRA code: 299.

By species: Horse (28 reports), Dog (13 reports), Cat (4 reports). By breed: Horse (unknown) (12), Crossbred Canine/dog (4), Thoroughbred (4).

Most co-reported drugs: Ivermectin, Praziquantel (20 reports), Hexetidine (2 reports), Deracoxib (2 reports), Ponazuril (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.