Reaction profile

The FDA adverse-event record for blue eye

29 FDA adverse-event reports reference blue eye (VeDDRA 414). See the species, breeds, and drugs most associated with it below.

29
reports citing this reaction
20.7%
death-coded share
Dog
most-affected species
Afoxolaner
most-associated drug
Verify with FDA CVM →
29
Total Reports
6
Deaths
20.7%
Death Rate

Species Most Affected

Dog 26
Cat 2
Cattle 1

Breeds Most Affected

Chihuahua 5
Crossbred Canine/dog 4
Terrier - Yorkshire 2
Spaniel - Cocker American 2
Terrier - Boston 2
Retriever - Labrador 2
Chow Chow 1
Deutsche Dogge, Great Dane 1
Maltese 1
Terrier - Jack Russell 1

Associated Drugs

Afoxolaner 4
Maropitant Citrate 3
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 3
Doxycycline 3
Ivermectin + Pyrantel As Pamoate Salt 3
Milbemycin Oxime + Praziquantel 3
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Coronavirus, Strain 2
Ivermectin 2
Ampicillin 2
Orbifloxacin 2
Spinosad 2
Carprofen 2
Meloxicam 2
Nitenpyram 2
Rabies Vaccine 2
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 2
Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate) 1
Enrofloxacin 1
Bacitracin, Neomyxin & Polymyxin B 1
Prednisolone 1

Blue eye Reaction Insights

29 reports name Blue eye; 6 recorded a death outcome (20.7% of reported events, not a population-level mortality rate). VeDDRA code: 414.

By species: Dog (26 reports), Cat (2 reports), Cattle (1 reports). By breed: Chihuahua (5), Crossbred Canine/dog (4), Terrier - Yorkshire (2).

Most co-reported drugs: Afoxolaner (4 reports), Maropitant Citrate (3 reports), Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St (3 reports), Doxycycline (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.