Reaction profile

The FDA adverse-event record for bilirubin(direct) high, blood

Name: BILIRUBIN(DIRECT) HIGH, BLOOD - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

28 FDA reports name bilirubin(direct) high, blood, a lower-volume reaction in the CVM extract (VeDDRA 99196). Plate stamps and neighbourhood peers follow.

#2021 of 2,481
by report volume (all reactions): 28
reports citing this reaction: 35.7%
death-coded share: Dog
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. BILIRUBIN(DIRECT) HIGH, BLOOD has 28 reports now versus 28 in that prior snapshot: 0 the same number of (0.0%).

Report change: +0
Death-coded reports: +0
Death-coded share: −0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to BILIRUBIN(DIRECT) HIGH, BLOOD changes

FDA AER · VeDDRA plate

Code 99196 VOL-TRACE

VOL-TRACE · DEATH-HOT · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-TRACE 28 reports
DEATH-HOT 35.7%
LOWER-Q #2021/2481
PHOTO-FINISH Absence seizure
SPECIES-DOG Dog · 24
DRUG-LEAD Carprofen · 11
DESK-WIDE 16 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Absence seizure (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around BILIRUBIN HIGH, BLOOD

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around BILIRUBIN(DIRECT) HIGH, BLOOD

BILIRUBIN(DIRECT) HIGH, BLOOD: high death-coded share in the FDA AER plate

Signature read: 28 reports place BILIRUBIN(DIRECT) HIGH, BLOOD in the lower third of FDA AER volume (#2021 of 2,481). Report volume is lower-third scale: 28 named reports in the openFDA extract. Death-coded share is upper-third: 10 of 28 reports (35.7% of named reports). Nearest volume peer: Absence seizure (±0 reports). Lead species Dog (24). Lead co-reported drug Carprofen (11).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 24

Cat 3

Horse 1

Breeds Most Affected

Retriever - Labrador 8

Retriever - Golden 3

Spaniel - Cocker American 2

Domestic (unspecified) 2

Crossbred Canine/dog 2

Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 1

Spaniel - Irish Water 1

Pointer (unspecified) 1

Sheepdog - Shetland 1

Domestic Shorthair 1

Associated Drugs

Carprofen 11

Deracoxib 2

Glycosaminoglycan Polysulfate 2

Ivermectin + Pyrantel As Pamoate Salt 2

Afoxolaner 2

Amoxicillin, Clavulanate 1

Cyclosporine 1

Firocoxib 1

Cefovecin Sodium 1

Doxycycline 1

Methimazole 1

Pimobendan 1

Clotrimazole, Gentamicin Sulfate, Mometasone Furoate Monohydrate 1

Selamectin 1

Ampicillin 1

Pergolide Mesylate 1

Flunixin 1

Ranitidine 1

Omeprazole 1

Masitinib Mesylate 1

What to do with this reaction

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for BILIRUBIN(DIRECT) HIGH, BLOOD (#2021 of 2,481 by report volume); death-coded 35.7%. PlainBreed reaction plate · report volume stamp 28 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →