Reaction profile

The FDA adverse-event record for bilirubin(direct) high, blood

28 FDA adverse-event reports reference bilirubin(direct) high, blood (VeDDRA 99196). See the species, breeds, and drugs most associated with it below.

28
reports citing this reaction
35.7%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
28
Total Reports
10
Deaths
35.7%
Death Rate

Species Most Affected

Dog 24
Cat 3
Horse 1

Breeds Most Affected

Retriever - Labrador 8
Retriever - Golden 3
Spaniel - Cocker American 2
Domestic (unspecified) 2
Crossbred Canine/dog 2
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 1
Spaniel - Irish Water 1
Pointer (unspecified) 1
Domestic Shorthair 1
Sheepdog - Shetland 1

Associated Drugs

Carprofen 11
Deracoxib 2
Glycosaminoglycan Polysulfate 2
Ivermectin + Pyrantel As Pamoate Salt 2
Afoxolaner 2
Amoxicillin, Clavulanate 1
Cyclosporine 1
Firocoxib 1
Cefovecin Sodium 1
Doxycycline 1
Methimazole 1
Pimobendan 1
Selamectin 1
Ampicillin 1
Clotrimazole, Gentamicin Sulfate, Mometasone Furoate Monohydrate 1
Pergolide Mesylate 1
Flunixin 1
Ranitidine 1
Omeprazole 1
Masitinib Mesylate 1

BILIRUBIN(DIRECT) HIGH, BLOOD Reaction Insights

28 reports name BILIRUBIN(DIRECT) HIGH, BLOOD; 10 recorded a death outcome (35.7% of reported events, not a population-level mortality rate). VeDDRA code: 99196.

By species: Dog (24 reports), Cat (3 reports), Horse (1 reports). By breed: Retriever - Labrador (8), Retriever - Golden (3), Spaniel - Cocker American (2).

Most co-reported drugs: Carprofen (11 reports), Deracoxib (2 reports), Glycosaminoglycan Polysulfate (2 reports), Ivermectin + Pyrantel As Pamoate Salt (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.