Reaction profile

The FDA adverse-event record for bile duct inflammation

11 FDA reports name bile duct inflammation, a lower-volume reaction in the CVM extract (VeDDRA 1344). Plate stamps and neighbourhood peers follow.

#2408 of 2,481
by report volume (all reactions)
11
reports citing this reaction
45.5%
death-coded share
Dog
most-affected species
Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Bile duct inflammation has 11 reports now versus 11 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Bile duct inflammation changes

FDA AER · VeDDRA plate

Code 1344 VOL-TRACE

VOL-TRACE · DEATH-HOT · BOTTOM-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 11 reports
  • DEATH-HOT 45.5%
  • BOTTOM-DECILE #2408/2481
  • PHOTO-FINISH ABNORMAL PANCREATIC S…
  • SPECIES-DOG Dog · 7
  • DRUG-LEAD Milbemycin Oxime… · 2
  • DESK-WIDE 10 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: ABNORMAL PANCREATIC SPECIFIC LIPASE (PLI) (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Bile duct inflammation

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348ABNORMAL PANCREATIC S… · near11Aortic stenosis · near11Aqueous flare · near11Bile duct inflammation · thi…11Bowel torsion · near11Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Bile duct inflammation

Bile duct inflammation: high death-coded share in the FDA AER plate

Signature read: 11 reports place Bile duct inflammation in the lower third of FDA AER volume (#2408 of 2,481). Report volume is lower-third scale: 11 named reports in the openFDA extract. Death-coded share is upper-third: 5 of 11 reports (45.5% of named reports). Nearest volume peer: ABNORMAL PANCREATIC SPECIFIC LIPASE (PLI) (±0 reports). Lead species Dog (7). Lead co-reported drug Milbemycin Oxime + Spinosad (2).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 7
Cat 4

Breeds Most Affected

Beagle 2
Sheepdog - Shetland 1
Spaniel - King Charles Cavalier 1
Shepherd Dog - German 1
Domestic Shorthair 1
Persian 1
Maine Coon 1
Cat (unknown) 1
Poodle - Miniature 1
Hound - Basset 1

Associated Drugs

Milbemycin Oxime + Spinosad 2
Robenacoxib 2
Prescription Diet (Unknown) 1
Metronidazole 1
Firocoxib 57 Mg Chewable 1
Pyrantel Pamoate 1
Dhpp Vaccine 1
Bordetella Vaccine 1
Spinosad 1
Afoxolaner 1
Buprenorphine 1
Propofol 1
Sevoflurane 1
Butorphanol Tartrate 1
Midazolam 1
Lidocaine Injection 1
Mirtazapine 1
Amoxicillin 1
Probiotic 1
Estradiol 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Bile duct inflammation (#2408 of 2,481 by report volume); death-coded 45.5%. PlainBreed reaction plate · report volume stamp 11 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →