Reaction profile

The FDA adverse-event record for bile duct inflammation

Name: Bile duct inflammation - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://creativecommons.org/publicdomain/zero/1.0/

11 FDA adverse-event reports reference bile duct inflammation (VeDDRA 1344). See the species, breeds, and drugs most associated with it below.

11
reports citing this reaction: 45.5%
death-coded share: Dog
most-affected species: Milbemycin Oxime + Spinosad
most-associated drug

Compiled by PlainBreed Editorial, Pet Health Editorial Team

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Total Reports

Deaths

45.5%

Death Rate

Species Most Affected

Dog 7

Cat 4

Breeds Most Affected

Beagle 2

Sheepdog - Shetland 1

Spaniel - King Charles Cavalier 1

Shepherd Dog - German 1

Domestic Shorthair 1

Persian 1

Maine Coon 1

Cat (unknown) 1

Poodle - Miniature 1

Hound - Basset 1

Associated Drugs

Milbemycin Oxime + Spinosad 2

Robenacoxib 2

Prescription Diet (Unknown) 1

Metronidazole 1

Firocoxib 57 Mg Chewable 1

Pyrantel Pamoate 1

Dhpp Vaccine 1

Bordetella Vaccine 1

Spinosad 1

Afoxolaner 1

Buprenorphine 1

Propofol 1

Sevoflurane 1

Butorphanol Tartrate 1

Midazolam 1

Lidocaine Injection 1

Mirtazapine 1

Amoxicillin 1

Probiotic 1

Estradiol 1

Bile duct inflammation Reaction Insights

11 reports name Bile duct inflammation; 5 recorded a death outcome (45.5% of reported events, not a population-level mortality rate). VeDDRA code: 1344.

By species: Dog (7 reports), Cat (4 reports). By breed: Beagle (2), Sheepdog - Shetland (1), Spaniel - King Charles Cavalier (1).

Most co-reported drugs: Milbemycin Oxime + Spinosad (2 reports), Robenacoxib (2 reports), Prescription Diet (Unknown) (1 reports), Metronidazole (1 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.