Reaction profile

The FDA adverse-event record for application site haemorrhage

30 FDA adverse-event reports reference application site haemorrhage (VeDDRA 11). See the species, breeds, and drugs most associated with it below.

30
reports citing this reaction
3.3%
death-coded share
Cat
most-affected species
Selamectin
most-associated drug
Verify with FDA CVM →
30
Total Reports
1
Deaths
3.3%
Death Rate

Species Most Affected

Cat 17
Dog 13

Breeds Most Affected

Domestic Shorthair 13
Domestic Longhair 2
American Shorthair 1
Collie - Border 1
Mixed (Dog) 1
Collie - Smooth-haired 1
Shepherd Dog - German 1
Crossbred Canine/dog 1
Spaniel - Cocker American 1
Terrier - Yorkshire 1

Associated Drugs

Selamectin 10
Imidacloprid + Moxidectin 5
Carprofen 4
Florfenicol/Terbinafine Hydrochloride/Mometasone Furoate 3
Tromethamine/Disodium Edta/Ketoconazole 3
Saline 3
Ciprofloxacin 2
Otic Flush 2
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 2
Fluralaner/Moxidectin Spot-On 2
Unspecified Anesthetic 1
Antihistamines 1
Prednisone 1
Famotidine 1
Tramadol 1
Device: Ligating Clips For Surgery 1
Flumethrin-Imidacloprid 1
Device: Surgical Instruments 1
Mirtazapine 1
Odansetron 1

Application site haemorrhage Reaction Insights

30 reports name Application site haemorrhage; 1 recorded a death outcome (3.3% of reported events, not a population-level mortality rate). VeDDRA code: 11.

By species: Cat (17 reports), Dog (13 reports). By breed: Domestic Shorthair (13), Domestic Longhair (2), American Shorthair (1).

Most co-reported drugs: Selamectin (10 reports), Imidacloprid + Moxidectin (5 reports), Carprofen (4 reports), Florfenicol/Terbinafine Hydrochloride/Mometasone Furoate (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.