Reaction profile

The FDA adverse-event record for application site bruising

28 FDA adverse-event reports reference application site bruising (VeDDRA 8). See the species, breeds, and drugs most associated with it below.

28
reports citing this reaction
0.0%
death-coded share
Dog
most-affected species
Bupivacaine Lipsome Injectable Suspension
most-associated drug
Verify with FDA CVM →
28
Total Reports
0
Deaths
0.0%
Death Rate

Species Most Affected

Dog 15
Cat 10
Horse 2
Human 1

Breeds Most Affected

Domestic Shorthair 6
Shepherd Dog - German 3
Crossbred Canine/dog 2
Pit Bull 2
Domestic Longhair 2
Thoroughbred 1
Unknown 1
Spaniel - Cocker American 1
Cat (other) 1
Chihuahua 1

Associated Drugs

Bupivacaine Lipsome Injectable Suspension 5
Selamectin 4
Imidacloprid + Moxidectin 2
Sodium Chloride 2
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 2
Selamectin;Sarolaner 2
Fluralaner Spot-On Solution 2
Mirtazapine 2
Bupivacaine 2
Gabapentin 2
Ivermectin/Praziquantel Paste 1
Tylosin 1
Hydromorphone 1
Cefazolin 1
Midazolam 1
Famotidine 1
Maropitant Citrate 1
Prednisone 1
Diphenhydramine 1
Tramadol 1

Application site bruising Reaction Insights

28 reports name Application site bruising; 0 recorded a death outcome (0.0% of reported events, not a population-level mortality rate). VeDDRA code: 8.

By species: Dog (15 reports), Cat (10 reports), Horse (2 reports). By breed: Domestic Shorthair (6), Shepherd Dog - German (3), Crossbred Canine/dog (2).

Most co-reported drugs: Bupivacaine Lipsome Injectable Suspension (5 reports), Selamectin (4 reports), Imidacloprid + Moxidectin (2 reports), Sodium Chloride (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.