Reaction profile

The FDA adverse-event record for aortic stenosis

10 FDA adverse-event reports reference aortic stenosis (VeDDRA 231). See the species, breeds, and drugs most associated with it below.

10
reports citing this reaction
50.0%
death-coded share
Dog
most-affected species
Afoxolaner
most-associated drug
Verify with FDA CVM →
10
Total Reports
5
Deaths
50.0%
Death Rate

Species Most Affected

Dog 9
Cat 1

Breeds Most Affected

Retriever - Golden 2
Terrier - Black Russian 1
Bulldog 1
Boxer (German Boxer) 1
Domestic Shorthair 1
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 1
Rottweiler 1
Ridgeback - Rhodesian 1
Greyhound 1

Associated Drugs

Afoxolaner 3
Carprofen 3
Ivermectin/Pyrantel Chew. Dog 272Mcg/227Mg 1
Frontline Plus For Dog 1
Prednisolone; Trimeprazine Tartrate 1
Oclacitinib Maleate 1
Amoxicillin As Trihydrate; Clavulanate Potassium ( K-Clavulanate) 1
Cetirizine Hcl 1
Milbemycin Oxime + Spinosad 1
Triamcinolone 1
Glucosamine + Chondroitin 1
Hyaluronic Acid 1
Ivermectin + Pyrantel As Pamoate Salt 1
Florfenicol/Terbinafine Hydrochloride/Mometasone Furoate 1
Cefovecin Sodium 1
Maropitant Citrate 1
Subcutanesous Fluids 1
Mirtazapine 1
Vaccine 1
Moxidectin 1

Aortic stenosis Reaction Insights

10 reports name Aortic stenosis; 5 recorded a death outcome (50.0% of reported events, not a population-level mortality rate). VeDDRA code: 231.

By species: Dog (9 reports), Cat (1 reports). By breed: Retriever - Golden (2), Terrier - Black Russian (1), Bulldog (1).

Most co-reported drugs: Afoxolaner (3 reports), Carprofen (3 reports), Ivermectin/Pyrantel Chew. Dog 272Mcg/227Mg (1 reports), Frontline Plus For Dog (1 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.