Drug profile

The FDA adverse-event record for Estradiol Benzoate; Trenbolone Acetate

127 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Estradiol Benzoate; Trenbolone Acetate. See the species affected, top reactions, and outcomes below.

127
adverse-event reports
12.6%
death-coded share
Cattle
most-reported species
30
Increased sexual interest - top reaction
Verify with FDA CVM →
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
127
Total Reports
16
Deaths Reported
12.6%
Death Rate

Active Ingredients

Estradiol Benzoate; Trenbolone Acetate

Administration Routes

Unknown

Species Affected

Cattle 65
Unknown 62

Most Affected Breeds

Unknown 62
Holstein-Friesian also known as Holstein 32
Mixed (Cattle) 26
Aberdeen Angus 3
Cattle (other) 2
Jersey 1
Crossbred Bovine/Cattle 1

Most Reported Reactions

Increased sexual interest 30
Containers, Damaged 27
Device Defective NOS 26
Implant, Abnormal 14
Sexual disorder NOS (see 'Reproductive' for named sexual disorders) 11
Death 8
Death by euthanasia 5
Behavioural disorder NOS 5
Lack of efficacy - NOS 5
No sign 4
Recumbency 3
Dispenser, Abnormal 3

Outcome Breakdown

Outcome Unknown
54 (68.4%)
Died
12 (15.2%)
Recovered/Normal
7 (8.9%)
Euthanized
4 (5.1%)
Recovered with Sequela
2 (2.5%)

Estradiol Benzoate; Trenbolone Acetate Adverse Event Insights

127 reports name Estradiol Benzoate; Trenbolone Acetate; 16 recorded a death outcome (12.6% of reported events, not a population-level mortality rate). Active ingredient: Estradiol Benzoate; Trenbolone Acetate. Administration route: Unknown.

By species: Cattle (65 reports), Unknown (62 reports). By breed: Unknown (62), Holstein-Friesian also known as Holstein (32), Mixed (Cattle) (26).

Leading clinical signs: Increased sexual interest (30), Containers, Damaged (27), Device Defective NOS (26), Implant, Abnormal (14). Outcome, 79 coded reports: Outcome Unknown leads at 68.4%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.