Estradiol Benzoate; Trenbolone Acetate

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127 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
127
Total Reports
16
Deaths Reported
1260.0%
Death Rate

Active Ingredients

Estradiol Benzoate; Trenbolone Acetate

Administration Routes

Unknown

Species Affected

Cattle 65
Unknown 62

Most Affected Breeds

Unknown 62
Holstein-Friesian also known as Holstein 32
Mixed (Cattle) 26
Aberdeen Angus 3
Cattle (other) 2
Jersey 1
Crossbred Bovine/Cattle 1

Most Reported Reactions

Increased sexual interest 30
Containers, Damaged 27
Device Defective NOS 26
Implant, Abnormal 14
Sexual disorder NOS (see 'Reproductive' for named sexual disorders) 11
Death 8
Death by euthanasia 5
Behavioural disorder NOS 5
Lack of efficacy - NOS 5
No sign 4
Recumbency 3
Dispenser, Abnormal 3

Outcome Breakdown

Outcome Unknown
54 (68.4%)
Died
12 (15.2%)
Recovered/Normal
7 (8.9%)
Euthanized
4 (5.1%)
Recovered with Sequela
2 (2.5%)

Data Summary

Metric Value
Total adverse event reports 127
Reports involving death 16
Case-fatality rate (reported events) 1260.0%
Distinct species in reports 2
Distinct breeds in reports 7
Distinct reactions reported 20
Active ingredients on file 1

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER). Counts reflect voluntary reports only.

Estradiol Benzoate; Trenbolone Acetate Adverse Event Insights

The FDA Center for Veterinary Medicine database currently holds 127 adverse event reports referencing Estradiol Benzoate; Trenbolone Acetate, including 16 reports in which the animal died — a 1260.0% case-fatality figure among reported events only, not a population-level mortality rate. Active ingredient on file: Estradiol Benzoate; Trenbolone Acetate. Reported administration route is Unknown. These numbers reflect voluntary submissions from pet owners, veterinarians, and manufacturers and therefore under-represent mild events and over-represent severe ones — a pattern the FDA has documented repeatedly for pharmacovigilance datasets.

The species most frequently named in Estradiol Benzoate; Trenbolone Acetate reports are Cattle (65 reports), Unknown (62 reports), with Cattle accounting for the largest share. Within those species, Unknown (62), Holstein-Friesian also known as Holstein (32), Mixed (Cattle) (26) appear most often — though breed popularity and ownership density shape these counts as much as any drug-specific sensitivity. This distribution matters because the same active ingredient can behave very differently across body sizes, ages, and species physiology.

The most commonly reported clinical signs associated with Estradiol Benzoate; Trenbolone Acetate are Increased sexual interest (30), Containers, Damaged (27), Device Defective NOS (26), Implant, Abnormal (14). Of the 79 reports with a coded outcome, Outcome Unknown is the leading category at 68.4%. Because FDA adverse event data describes correlation rather than causation, these figures are best used to frame informed questions with a veterinarian and to compare reporting patterns across related products — not as a standalone safety verdict on Estradiol Benzoate; Trenbolone Acetate.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial