Dinotefuran, Permethrin, Pyriproxyfen
127 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
127
Total Reports
10
Deaths Reported
790.0%
Death Rate
Active Ingredients
Dinotefuran, Permethrin, Pyriproxyfen
Administration Routes
TopicalUnknownOral
Species Affected
Dog 116
Cat 11
Most Affected Breeds
Retriever - Labrador 17
Terrier - Bull - American Pit 8
Retriever - Golden 6
Domestic Shorthair 6
Shepherd Dog - German 6
Dachshund (unspecified) 5
Terrier - Yorkshire 4
Crossbred Canine/dog 4
Shih Tzu 4
Shepherd Dog - Australian 3
Most Reported Reactions
Lethargy (see also Central nervous system depression in 'Neurological') 27
Vomiting 24
Lack of efficacy - NOS 14
Other abnormal test result NOS 14
Diarrhoea 13
Anorexia 11
Elevated alanine aminotransferase (ALT) 11
Elevated serum alkaline phosphatase (SAP) 11
Behavioural disorder NOS 11
INEFFECTIVE, HEARTWORM LARVAE 9
Fever 9
Weight loss 9
Outcome Breakdown
Ongoing
77 (60.6%)
Recovered/Normal
25 (19.7%)
Outcome Unknown
15 (11.8%)
Euthanized
6 (4.7%)
Died
4 (3.1%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.