Drug profile

The FDA adverse-event record for Amoxicillin + Clavulanic Acid

263 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Amoxicillin + Clavulanic Acid. See the species affected, top reactions, and outcomes below.

263
adverse-event reports
11.8%
death-coded share
Dog
most-reported species
51
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
263
Total Reports
31
Deaths Reported
11.8%
Death Rate

Active Ingredients

AmoxicillinAmoxicillin + Clavulanic AcidClavulanic Acid

Administration Routes

UnknownOralAuricular (Otic)

Species Affected

Dog 152
Cat 107
Human 3
Unknown 1

Most Affected Breeds

Domestic Shorthair 73
Retriever - Labrador 15
Cat (unknown) 10
Shih Tzu 9
Domestic Longhair 9
Retriever - Golden 6
Spitz - German Pomeranian 6
Bulldog - French 6
Unknown 5
Pointing Dog - Hungarian Short-haired (Vizsla) 5

Most Reported Reactions

Vomiting 51
Lethargy (see also Central nervous system depression in Neurological) 39
Other abnormal test result NOS 38
Decreased appetite 36
Not eating 32
Diarrhoea 27
Weight loss 27
Death by euthanasia 26
Elevated alanine aminotransferase (ALT) 24
Behavioural disorder NOS 24
Leucocytosis NOS 23
Hyperglycaemia 23

Outcome Breakdown

Ongoing
99 (37.6%)
Outcome Unknown
87 (33.1%)
Recovered/Normal
45 (17.1%)
Euthanized
25 (9.5%)
Died
6 (2.3%)
Recovered with Sequela
1 (0.4%)

Amoxicillin + Clavulanic Acid Adverse Event Insights

263 reports name Amoxicillin + Clavulanic Acid; 31 recorded a death outcome (11.8% of reported events, not a population-level mortality rate). Active ingredients: Amoxicillin, Amoxicillin + Clavulanic Acid, Clavulanic Acid. Administration routes: Unknown, Oral, Auricular (Otic).

By species: Dog (152 reports), Cat (107 reports), Human (3 reports). By breed: Domestic Shorthair (73), Retriever - Labrador (15), Cat (unknown) (10).

Leading clinical signs: Vomiting (51), Lethargy (see also Central nervous system depression in Neurological) (39), Other abnormal test result NOS (38), Decreased appetite (36). Outcome, 263 coded reports: Ongoing leads at 37.6%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.