Drug profile

The FDA adverse-event record for Trimeprazine Tartrate;Prednisolone

332 FDA reports name Trimeprazine Tartrate;Prednisolone, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#392 of 2,679
by report volume (all drugs)
332
adverse-event reports
11.4%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Trimeprazine Tartrate;Prednisolone ranks #391 of 2679 by total reports (332) and #481 of 1130 by death-coded share (11.4%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#391
This drug, reports of 2679
#481
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Trimeprazine Tartrate;Prednisolone has 332 reports now versus 328 in that prior snapshot: 4 more (1.2%).

Report change
+4
Death-coded reports
+1
Death-coded share
+0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Trimeprazine Tartrate;Prednisolone changes

Signature read: death-coded report count at 38 is the most distinctive stamp on Trimeprazine Tartrate;Prednisolone's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
332
Total Reports
38
Deaths Reported
11.4%
Death-coded share of reports

Active Ingredients

Trimeprazine Tartrate;Prednisolone

Administration Routes

OralUnknownSubcutaneous

Species Affected

Dog 310
Unknown 20
Other 1
Cat 1

Most Affected Breeds

Chihuahua 25
Retriever - Labrador 23
Unknown 21
Shih Tzu 18
Dog (unknown) 13
Maltese 13
Terrier - Yorkshire 13
Terrier - Bull - American Pit 12
Retriever - Golden 11
Bulldog - French 10

Most Reported Reactions

Lack of efficacy - NOS 68
Vomiting 41
Lethargy (see also Central nervous system depression in 'Neurological') 36
Diarrhoea 28
Panting 22
Cough 22
Seizure NOS 20
Death 19
Polydipsia 19
Anorexia 17
Elevated serum alkaline phosphatase (SAP) 17
Polyuria 17

Outcome Breakdown

Ongoing
194 (62.2%)
Outcome Unknown
49 (15.7%)
Recovered/Normal
30 (9.6%)
Died
22 (7.1%)
Euthanized
16 (5.1%)
Recovered with Sequela
1 (0.3%)

Trimeprazine Tartrate;Prednisolone: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Trimeprazine Tartrate;Prednisolone, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (11.4% here), distinct from the volume row.

What to do with this drug

  • Compare Trimeprazine Tartrate;Prednisolone's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Trimeprazine Tartrate;Prednisolone (#392 of 2,679 by report volume); death-coded 11.4%. PlainBreed drug row · death-coded report count stamp 38 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →