Total Reports
5
FDA CVM filings
Cattle /
2026 FDA CVM data 5 reports on file official source
Highland — FDA Adverse Event Profile
Adverse-event records and label data for Highland (Cattle), sourced from the FDA Center for Veterinary Medicine. Refreshed as new reports are filed. Cite PlainBreed when reusing this analysis.
Highland (Cattle) has 5 FDA adverse event reports on record, with 4 deaths reported (8000.0% death rate) — ranking #504 by report volume. The most frequently reported reaction is Death (4 cases). The top associated drug is Doramectin. Average age at report: 2.9 years.
Deaths Reported
4
of 5 reports
Death Rate
8000.0%
death-coded share
Avg Age at Report
2.9 yr
294.8 kg avg weight
Death-Coded Outcome Share
Highland death-coded reports 100.0%
Database median
8000.0% of 5 reports involved a death outcome. Read alongside breed popularity, veterinary access, and owner awareness — these shape how many events ever reach the FDA. The 12% comparison line is the rough cross-breed median in the FDA CVM database; values above suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 294.8 kg (650.0 lbs)
Top Reported Reactions
Death 4
Lethargy (see also Central nervous system depression in Neurological) 2
INEFFECTIVE, LICE BITING 1
Agitation 1
Lack of efficacy - NOS 1
Most Referenced Drugs
Doramectin 4
Ceftiofur Crystalline Free Acid 2
Bovine Viral Diarrhea Virus, Type 1, Strain 5960, Lot 51383;Bovine Viral Diarrhe 2
Fenbendazol Suspension 2
Clostr Perf*2/Clos Others*6 Kb 2
Bovilis Cavalry 9 1
Panacur 1
Ibr, Bvd, Pi3, Brsv, Lepto 1
Ceftiofur 1
Vit E/ Selenite Inj Solution 1
Clostr Perf*2/Clos Others*5 Kb 1
Bvd Brsv Pi 3 1
Moraxcella Bovis 1
Rabies 1
Histophilus 1
Outcome Breakdown
Died
4 (80.0%)
Outcome Unknown
1 (20.0%)
Gender Distribution
Female 4 (80.0%)
Mixed 1 (20.0%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2020 | 1 | |
| 2024 | 4 | |
Highland Pet Health Insights
Across the FDA Center for Veterinary Medicine adverse event database, Highland accounts for 5 submitted reports and currently ranks #504 by report volume within the cattle population. Of those reports, 4 involved a death outcome — a 8000.0% case-fatality figure calculated directly from the underlying FDA records rather than from external mortality studies. The mean age at time of reporting is 2.9 years, with an average recorded body weight of 294.8 kg (650.0 lbs). These figures reflect the voluntary reporting pool only and should be read alongside breed popularity, veterinary access, and owner awareness — all of which shape how many events ever reach the FDA.
The most frequently reported clinical signs for Highland are Death (4 reports), Lethargy (see also Central nervous system depression in Neurological) (2 reports), INEFFECTIVE, LICE BITING (1 reports), together capturing a substantial share of the top-reaction traffic seen in this breed's record. On the product side, Doramectin appears in 4 reports and is the single most-referenced drug, followed by Ceftiofur Crystalline Free Acid (2) and Bovine Viral Diarrhea Virus, Type 1, Strain 5960, Lot 51383;Bovine Viral Diarrhe (2). Counts like these surface which therapeutic classes dominate the reporting stream — useful context when comparing reactions across breeds of the same cattle species.
Outcome coding on the 5 reports with a recorded status is dominated by Died (80.0% of coded outcomes). Annual submission volume ranges from 2,020 to 2,024 reports across the 2 years on file, indicating the reporting trend is shaped as much by awareness cycles as by underlying clinical events. Because FDA adverse event reports describe correlation rather than causation, these numbers are most useful as a signal of where to ask further questions with a veterinarian — not as a standalone risk score for any individual cattle.
Understanding Highland Adverse Event Data
Highland has 5 adverse event reports on file. Lower report volumes may reflect a less common breed, lower reporting rates, or genuinely fewer adverse events.
The 8000.0% death rate is above average, though this statistic should be interpreted cautiously. Death reports may be overrepresented because serious outcomes are more likely to be reported than mild reactions.
The most frequently referenced drug in adverse reports is Doramectin, appearing in 4 reports. This may indicate widespread use of the medication rather than a specific safety concern for Highland.
Other Cattle Breeds
Holstein-Friesian also known as Holstein
3,106 reports · 3890.0% death rate
Cattle (other)
2,996 reports · 4880.0% death rate
Mixed (Cattle)
2,581 reports · 4740.0% death rate
Cattle (unknown)
2,424 reports · 3850.0% death rate
Aberdeen Angus
1,610 reports · 3480.0% death rate
Crossbred Bovine/Cattle
1,357 reports · 4970.0% death rate
Frequently Asked Questions
How many FDA adverse event reports involve Highland? ▼
There are 5 adverse event reports involving Highland in the FDA database, with 4 reports involving death (8000.0% death rate). Highland ranks #504 by report volume.
What are the most common adverse reactions reported for Highland? ▼
The most commonly reported adverse reactions for Highland are Death (4 reports), Lethargy (see also Central nervous system depression in Neurological) (2 reports), INEFFECTIVE, LICE BITING (1 reports), Agitation (1 reports), Lack of efficacy - NOS (1 reports).
What drugs are most frequently associated with Highland adverse events? ▼
The drugs most frequently referenced in Highland adverse event reports are Doramectin (4 reports), Ceftiofur Crystalline Free Acid (2 reports), Bovine Viral Diarrhea Virus, Type 1, Strain 5960, Lot 51383;Bovine Viral Diarrhe (2 reports), Fenbendazol Suspension (2 reports), Clostr Perf*2/Clos Others*6 Kb (2 reports).
What is the average age of Highland in adverse event reports? ▼
The average age of Highland at the time of adverse event reports is 2.9 years, with an average weight of 294.8 kg (650.0 lbs).
Does a high number of adverse event reports mean Highland is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Highland safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Guides & Resources
Understanding Adverse Events
What FDA reports are and how they are collected
Breed-Specific Risks
Why some breeds appear in more adverse event reports
Pet Medication Safety
Evaluating medication risks using FDA data
Most Reported Medications
Drugs that appear most in adverse event reports
How FDA CVM Tracks Events
The reporting process and database limitations
Related Data Sources
Data Sources & Methodology
Adverse event data sourced from the FDA Center for Veterinary Medicine via the openFDA Animal & Veterinary Adverse Events API. Reports are voluntarily submitted by pet owners, veterinarians, and product manufacturers.
Highland ranks #504 by total report volume. Death rate (8000.0%) reflects the proportion of reports involving death and should not be interpreted as a breed-specific mortality rate. Reporting biases, breed popularity, and veterinary access all influence report counts.
Read our methodology — how this data is sourced, computed, and verified.
Related
Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial