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Breed profile · FDA CVM July 2026 extract

Holstein-Friesian also known as Holstein adverse-event record

Adverse-event filings for Holstein-Friesian also known as Holstein (Cattle) in the FDA Center for Veterinary Medicine openFDA extract. Browse cattle breeds, reactions, and outcomes below.

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#59 of 510
by report volume (all breeds)
3,156
FDA CVM reports on file
38.9%
death-coded share of reports
#18 of 275
by death-coded share (≥50 reports)

How the 3,156 reports break down

By recorded gender -- every report on file for Holstein-Friesian also known as Holstein, no filtering.

Annual report volume

Annual adverse-event report trend Yearly FDA CVM adverse-event report counts for this breed. 152 114 76 38 0 2019 2020 2021 2022 2023 2024 2025 2026 Reports filed Death-coded reports
Annual report volume for Holstein-Friesian also known as Holstein drawn from FDA CVM filings.

Data updated September 2026

The verdict

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Holstein-Friesian also known as Holstein ranks #59 of 510 by total reports (3,156) and #18 of 275 by death-coded share (38.9%). National dual: Retriever - Labrador is #1 of 510 by total adverse-event reports (93,675) at death-coded-share rank 195 of 275 breeds with at least 50 reports (3.7%); separately, Atlantic Salmon (Salmo salar) is #1 highest death-coded share at 99.0% (report rank #233).

93,675
Retriever - Labrador reports (#1)
99.0%
Atlantic Salmon (Salmo salar) death share (#1)
#59
This breed, reports of 510
#18
This breed, death share of 275

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Holstein-Friesian also known as Holstein has 3,156 reports now versus 3,133 in that prior snapshot: 23 more (0.7%).

Report change
+23
Death-coded reports
+7
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Holstein-Friesian also known as Holstein changes

Total Reports

3,156

High report volume

Deaths Reported

1,229

of 3,156 reports

Death-coded share of reports

38.9%

Highest death-coded share

Avg Age at Report

1.7 yr

194.9 kg avg weight

Breed Safety Scorecard

F (21/100)

A weighted composite across 4 of 4 dimensions, each benchmarked against every tracked breed with at least 200 reports (n=185). Dimensions with insufficient data drop out and their weight redistributes to the rest, so a missing input never silently deflates the score.

Death rate F
38.9%

Share of reports coded as a fatality

Euthanasia rate F
4.6%

Share of reports resulting in euthanasia

Full recovery rate F
19.1%

Share of reports coded "Recovered/Normal"

5-year trend A-
-26%

Change in annual report volume over the last 5 complete years

Death-Coded Outcome Share

Holstein-Friesian also known as Holstein death-coded reports 38.9%
Cross-breed median

38.9% of 3,156 holstein-friesian also known as holstein reports involved a death outcome.

How to read this number

Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.

Where Holstein-Friesian also known as Holstein's death-coded share sits among indexed breeds

Death-coded share of FDA CVM reports, breeds with ≥50 reports (July 2026 extract)

39% 93rd percentile Higher share than 93% of 275 indexed breeds

5%–10%: 1 indexed breeds (0%). Below this entry. 20%–25%: 2 indexed breeds (1%). Below this entry. 25%–30%: 3 indexed breeds (1%). Below this entry. 30%–35%: 4 indexed breeds (1%). Below this entry. 35%–40%: 5 indexed breeds (2%). This entry sits in this band. 40%–45%: 6 indexed breeds (2%). Above this entry. 45%–50%: 3 indexed breeds (1%). Above this entry. 50%–55%: 7 indexed breeds (3%). Above this entry. 55%–60%: 7 indexed breeds (3%). Above this entry. 60%–65%: 21 indexed breeds (8%). Above this entry. 65%–70%: 11 indexed breeds (4%). Above this entry. 70%–75%: 15 indexed breeds (5%). Above this entry. 75%–80%: 13 indexed breeds (5%). Above this entry. 80%–85%: 11 indexed breeds (4%). Above this entry. 85%–90%: 12 indexed breeds (4%). Above this entry. 90%–95%: 12 indexed breeds (4%). Above this entry. 95%–100%: 142 indexed breeds (52%). Above this entry. Holstein-Friesian also known as Holstein 5% 100% every breed with ≥50 FDA reports, bucketed by value

Each bar is a band; taller bars hold more indexed breeds. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count, share, and where it sits relative to this entry.

Source FDA Center for Veterinary Medicine, openFDA adverse event extract (PlainBreed) · July 2026 extract

This histogram uses the same ≥50-report cohort as the highest death-coded share ranking. A higher share means more of this breed's reported events were death-coded, not a mortality rate for living animals.

Holstein-Friesian also known as Holstein among report-volume vs. death-rate peers

Every breed shown has at least 50 filed reports. Volume reflects how often a breed is reported, not how common it is; death rate is the share of a breed's own reports coded as a death outcome.

Source: FDA openFDA Animal & Veterinary Adverse Events database 2×2 strategic matrix plotting 30 entities by Total Reports (X) and Death Rate (%) (Y), with a crosshair dividing the plot into four quadrants. High volume, high death rateLow volume, high death rateHigh volume, low death rateLow volume, low death rate 020,00040,00060,00080,000100,000 0%5%10%15% Total Reports Death Rate (%) Holstein-Friesian also known as Holstein vs. all breeds, report volume and death-coded share Retriever - Labrador-93675, 3.7%Crossbred Canine/dog-70591, 3.2%Domestic Shorthair-65226, 7.2%Dog (unknown)-48820, 8.8%Retriever - Golden-35980, 3.7%Shepherd Dog - German-32220, 4.4%Chihuahua-31521, 4.2%Terrier - Yorkshire-24924, 3.7%Shih Tzu-24405, 3.6%Boxer (German Boxer)-19405, 4.4%Beagle-17970, 3.6%Pit Bull-17865, 3.1%Shepherd Dog - Australian-16274, 3.7%Terrier (unspecified)-14058, 3.1%Maltese-13940, 3.2%Dachshund (unspecified)-13512, 4.6%Cat (unknown)-13248, 9.3%Terrier - Jack Russell-10423, 3.7%Collie - Border-10130, 4.3%Siberian Husky-9811, 4.5%Domestic Longhair-9615, 7%Pug-9224, 5.2%Spitz - German Pomeranian-9086, 4.9%Terrier - Bull - American Pit-8769, 4.7%Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog)-7871, 3.6%Terrier - Boston-7737, 4.5%Spaniel - Cocker American-7640, 4%Domestic (unspecified)-7576, 13.4%Poodle (unspecified)-7534, 3.4%Schnauzer - Miniature-7513, 4.4%
Source: FDA openFDA Animal & Veterinary Adverse Events database
Average weight at time of report: 194.9 kg (429.8 lbs)

Top Reported Reactions

Death 928
Lack of efficacy (bacteria) - NOS 309
Lack of efficacy - NOS 301
Milk production decrease 211
Residues in milk 191
Diarrhoea 170
Lack of efficacy (protozoa) - Coccidia 142
Alteration of milk quality 136
INEFFECTIVE, PRODUCTION (MILK) 122
Injection site swelling 117
Residues in meat/offal 113
Mastitis NOS 108
Death by euthanasia 103
CULTURE/TITER DATA ABNORMAL 102
Recumbency 101

Most Referenced Drugs

Monensin Sodium 862
Sometribove 257
Cephapirin Sodium 200
Ceftiofur Hydrochloride 174
Ceftiofur Crystalline Free Acid 140
Tulathromycin 138
Dinoprost Tromethamine 110
Eprinomectin 79
Ampicillin Trihydrate 75
Cloxacillin Benz Intramam Dc 73
Florfenicol, Flunixin 62
Tildipirosin 61
Pegbovigrastim 61
Moxidectin 60
Cloxacillin Benzathine 58

Outcome Breakdown

Outcome Unknown
1,316 (37.7%)
Died
1,120 (32.1%)
Recovered/Normal
604 (17.3%)
Ongoing
208 (6.0%)
Euthanized
145 (4.2%)
Recovered with Sequela
96 (2.8%)

Gender Distribution

Female 2,451 (77.7%)
Male 450 (14.3%)
Unknown 152 (4.8%)
Mixed 103 (3.3%)

Reports by Year

Year Reports Trend
2010 169
2011 197
2012 334
2013 310
2014 311
2015 318
2016 275
2017 295
2018 210
2019 129
2020 152
2021 116
2022 82
2023 75
2024 81
2025 86
2026 16

Holstein-Friesian also known as Holstein: high death-coded share in the FDA CVM extract

Signature read: Holstein-Friesian also known as Holstein's 38.9% death-coded share is in the upper third of the ≥50-report cohort (median 4.8%). According to FDA CVM filings indexed on PlainBreed as of July 2026 extract, Holstein-Friesian also known as Holstein sits at #59 of 510 by report volume among all breeds and #1 of 30 among cattle breeds, with 3,156 reports and 1,229 (38.9%) death-coded. On death-coded share among breeds with ≥50 reports, it ranks #18 of 275. Mean age at report: 1.7 years, average weight 194.9 kg (429.8 lbs).

Top reported signs: Death (928), Lack of efficacy (bacteria) - NOS (309), Lack of efficacy - NOS (301). Most-referenced drug: Monensin Sodium (862 reports), followed by Sometribove (257) and Cephapirin Sodium (200).

Outcome coding on 3,489 status-recorded reports is dominated by Outcome Unknown (37.7%). Annual submissions ranged 16-2,026 across 17 years on file.

Cattle Breeds With a Similar Report Volume

Showing 6 of 29 cattle breeds in our dataset, ranked by closest report volume.

Cattle (other)
3,054 reports · 49.0% death-coded
Mixed (Cattle)
2,695 reports · 48.3% death-coded
Cattle (unknown)
2,461 reports · 39.0% death-coded
Aberdeen Angus
1,639 reports · 35.1% death-coded
Crossbred Bovine/Cattle
1,379 reports · 50.2% death-coded
Jersey
333 reports · 37.8% death-coded

Nationwide breeds with similar profiles

High-volume peer sets for Holstein-Friesian also known as Holstein drawn from openFDA outside the Cattle family so the neighborhoods are not species containment (the similar-volume list above stays within species).

Similar death-coded share

Nearest other-species breeds with ≥50 reports (38.9% death-coded here).

Goat (unknown) 36.9% · Goat Rabbit (other) 36.5% · Rabbit Crossbred Porcine/Pig 44.2% · Pig Rabbit (unknown) 31.0% · Rabbit

Similar average weight

Nearest other-species breeds by reported average weight (194.9 kg here).

Donkey (unknown) 201.4 kg · Donkey Donkey (other) 186.8 kg · Donkey Shetland Pony 179.0 kg · Horse Shire 238.1 kg · Horse

What to do with this cattle

A report does not prove a drug caused the reaction, and popular breeds simply generate more reports.

Frequently Asked Questions

How many FDA adverse event reports involve Holstein-Friesian also known as Holstein? ▼
There are 3,156 adverse event reports involving Holstein-Friesian also known as Holstein in the FDA database, of which 1,229 were death-coded (38.9% of those reports). That is a share of REPORTED events, not a mortality rate for the breed: adverse events reach the FDA when something goes wrong, so the denominator is reports, never the population of animals. According to the same FDA CVM extract, Holstein-Friesian also known as Holstein ranks #59 of 510 by report volume among all breeds PlainBreed indexes (#1 of 30 among cattle breeds).
Where does Holstein-Friesian also known as Holstein sit among other breeds in PlainBreed's corpus? ▼
According to FDA CVM report volume, Holstein-Friesian also known as Holstein is #59 of 510 breeds indexed on PlainBreed (same ordering as the most-reported-breeds ranking). Inside Cattle, it is #1 of 30. Among breeds with at least 50 reports, its death-coded share ranks #18 of 275 (same cohort as highest-death-rate). These are placement ranks in the reporting corpus, not clinical risk scores.
What are the most common adverse reactions reported for Holstein-Friesian also known as Holstein? ▼
The most commonly reported adverse reactions for Holstein-Friesian also known as Holstein are Death (928 reports), Lack of efficacy (bacteria) - NOS (309 reports), Lack of efficacy - NOS (301 reports), Milk production decrease (211 reports), Residues in milk (191 reports).
What drugs are most frequently associated with Holstein-Friesian also known as Holstein adverse events? ▼
The drugs most frequently referenced in Holstein-Friesian also known as Holstein adverse event reports are Monensin Sodium (862 reports), Sometribove (257 reports), Cephapirin Sodium (200 reports), Ceftiofur Hydrochloride (174 reports), Ceftiofur Crystalline Free Acid (140 reports).
What is the average age of Holstein-Friesian also known as Holstein in adverse event reports? ▼
The average age of Holstein-Friesian also known as Holstein at the time of adverse event reports is 1.7 years, with an average weight of 194.9 kg (429.8 lbs).

Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how the death-coded share and rankings are computed, or read breed-specific reporting patterns and FDA CVM reporting.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Holstein-Friesian also known as Holstein (Cattle), extract as of July 2026 extract. 3,156 reports · 1,229 death-coded (38.9% of reports, not a mortality rate) · #59 of 510 by volume.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →