Total Reports
3,106
FDA CVM filings
Cattle /
FDA CVM · 2025 release 3,106 reports on file
Holstein-Friesian also known as Holstein - FDA Adverse Event Profile
Adverse-event records for Holstein-Friesian also known as Holstein (Cattle) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
Holstein-Friesian also known as Holstein ranks #58 by report volume among cattle breeds - 1,207 of 3,106 reports (38.9%) recorded a death outcome.
- #58
- most-reported cattle breed
- 38.9%
- death-coded report share
- 911
- Death - top reaction
- 1.7 yr
- average age at report
Report counts track breed popularity and reporting activity, not real-world risk, read this alongside how common the breed is.
Deaths Reported
1,207
of 3,106 reports
Death Rate
38.9%
death-coded share
Avg Age at Report
1.7 yr
194.7 kg avg weight
Death-Coded Outcome Share
Holstein-Friesian also known as Holstein death-coded reports 38.9%
Cross-breed median
38.9% of 3,106 holstein-friesian also known as holstein reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 194.7 kg (429.3 lbs)
Top Reported Reactions
Death 911
Lack of efficacy (bacteria) - NOS 306
Lack of efficacy - NOS 293
Milk production decrease 200
Residues in milk 190
Diarrhoea 165
Lack of efficacy (protozoa) - Coccidia 140
Alteration of milk quality 135
INEFFECTIVE, PRODUCTION (MILK) 122
Injection site swelling 116
Residues in meat/offal 112
Mastitis NOS 105
CULTURE/TITER DATA ABNORMAL 102
Recumbency 99
Death by euthanasia 98
Most Referenced Drugs
Monensin Sodium 838
Sometribove 257
Cephapirin Sodium 199
Ceftiofur Hydrochloride 174
Ceftiofur Crystalline Free Acid 139
Tulathromycin 138
Dinoprost Tromethamine 110
Eprinomectin 77
Ampicillin Trihydrate 73
Cloxacillin Benz Intramam Dc 69
Florfenicol, Flunixin 62
Tildipirosin 61
Pegbovigrastim 61
Moxidectin 60
Eprinomectin 5 Mg/Ml Pour-On Solution 57
Outcome Breakdown
Outcome Unknown
1,295 (37.8%)
Died
1,101 (32.1%)
Recovered/Normal
599 (17.5%)
Ongoing
194 (5.7%)
Euthanized
140 (4.1%)
Recovered with Sequela
96 (2.8%)
Gender Distribution
Female 2,411 (77.6%)
Male 445 (14.3%)
Unknown 148 (4.8%)
Mixed 102 (3.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 169 | |
| 2011 | 197 | |
| 2012 | 334 | |
| 2013 | 310 | |
| 2014 | 311 | |
| 2015 | 318 | |
| 2016 | 275 | |
| 2017 | 295 | |
| 2018 | 210 | |
| 2019 | 129 | |
| 2020 | 152 | |
| 2021 | 116 | |
| 2022 | 82 | |
| 2023 | 75 | |
| 2024 | 81 | |
| 2025 | 52 | |
Holstein-Friesian also known as Holstein Pet Health Insights
Holstein-Friesian also known as Holstein accounts for 3,106 FDA adverse event reports, ranking #58 by volume among cattle breeds, with 1,207 reports (38.9%) coded as a death outcome. Mean age at report: 1.7 years, average weight 194.7 kg (429.3 lbs).
Top reported signs: Death (911), Lack of efficacy (bacteria) - NOS (306), Lack of efficacy - NOS (293). Most-referenced drug: Monensin Sodium (838 reports), followed by Sometribove (257) and Cephapirin Sodium (199).
Outcome coding on 3,425 status-recorded reports is dominated by Outcome Unknown (37.8%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Cattle Breeds With a Similar Report Volume
Frequently Asked Questions
How many FDA adverse event reports involve Holstein-Friesian also known as Holstein? ▼
There are 3,106 adverse event reports involving Holstein-Friesian also known as Holstein in the FDA database, with 1,207 reports involving death (38.9% death rate). Holstein-Friesian also known as Holstein ranks #58 by report volume.
What are the most common adverse reactions reported for Holstein-Friesian also known as Holstein? ▼
The most commonly reported adverse reactions for Holstein-Friesian also known as Holstein are Death (911 reports), Lack of efficacy (bacteria) - NOS (306 reports), Lack of efficacy - NOS (293 reports), Milk production decrease (200 reports), Residues in milk (190 reports).
What drugs are most frequently associated with Holstein-Friesian also known as Holstein adverse events? ▼
The drugs most frequently referenced in Holstein-Friesian also known as Holstein adverse event reports are Monensin Sodium (838 reports), Sometribove (257 reports), Cephapirin Sodium (199 reports), Ceftiofur Hydrochloride (174 reports), Ceftiofur Crystalline Free Acid (139 reports).
What is the average age of Holstein-Friesian also known as Holstein in adverse event reports? ▼
The average age of Holstein-Friesian also known as Holstein at the time of adverse event reports is 1.7 years, with an average weight of 194.7 kg (429.3 lbs).
Does a high number of adverse event reports mean Holstein-Friesian also known as Holstein is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Holstein-Friesian also known as Holstein safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.