Cattle /

Holstein-Friesian also known as Holstein

3,106 adverse event reports submitted to the FDA

Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your cattle.
3,106
Total Reports
1,207
Deaths Reported
3890.0%
Death Rate
1.7 yr
Avg Age at Report
Average weight at time of report: 194.7 kg (429.3 lbs)

Top Reported Reactions

Death 911
Lack of efficacy (bacteria) - NOS 306
Lack of efficacy - NOS 293
Milk production decrease 200
Residues in milk 190
Diarrhoea 165
Lack of efficacy (protozoa) - Coccidia 140
Alteration of milk quality 135
INEFFECTIVE, PRODUCTION (MILK) 122
Injection site swelling 116
Residues in meat/offal 112
Mastitis NOS 105
CULTURE/TITER DATA ABNORMAL 102
Recumbency 99
Death by euthanasia 98

Most Referenced Drugs

Monensin Sodium 838
Sometribove 257
Cephapirin Sodium 199
Ceftiofur Hydrochloride 174
Ceftiofur Crystalline Free Acid 139
Tulathromycin 138
Dinoprost Tromethamine 110
Eprinomectin 77
Ampicillin Trihydrate 73
Cloxacillin Benz Intramam Dc 69
Florfenicol, Flunixin 62
Tildipirosin 61
Pegbovigrastim 61
Moxidectin 60
Eprinomectin 5 Mg/Ml Pour-On Solution 57

Outcome Breakdown

Outcome Unknown
1,295 (37.8%)
Died
1,101 (32.1%)
Recovered/Normal
599 (17.5%)
Ongoing
194 (5.7%)
Euthanized
140 (4.1%)
Recovered with Sequela
96 (2.8%)

Gender Distribution

Female 2,411 (77.6%)
Male 445 (14.3%)
Unknown 148 (4.8%)
Mixed 102 (3.3%)

Reports by Year

Year Reports Trend
2010 169
2011 197
2012 334
2013 310
2014 311
2015 318
2016 275
2017 295
2018 210
2019 129
2020 152
2021 116
2022 82
2023 75
2024 81
2025 52

Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #58 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.