Reaction profile

The FDA adverse-event record for walking on tiptoes

22 FDA adverse-event reports reference walking on tiptoes (VeDDRA 2389). See the species, breeds, and drugs most associated with it below.

22
reports citing this reaction
18.2%
death-coded share
Dog
most-affected species
Ivermectin + Pyrantel As Pamoate Salt
most-associated drug
Verify with FDA CVM →
22
Total Reports
4
Deaths
18.2%
Death Rate

Species Most Affected

Dog 15
Cat 6
Horse 1

Breeds Most Affected

Domestic Shorthair 4
Retriever - Labrador 4
Shepherd Dog - Australian 2
Rottweiler 1
Retriever - Golden 1
Warmblood - Swedish 1
Pit Bull 1
Crossbred Canine/dog 1
Cat (unknown) 1
Bulldog - French 1

Associated Drugs

Ivermectin + Pyrantel As Pamoate Salt 3
Pyrantel Pamoate;Sarolaner 3
Maropitant Citrate 3
Gabapentin 3
Buprenorphine 2
Melarsomine Dihydrochloride 2
Canine Parvovirus Strain Nl-35-D, P.35-D, 8-2-80;Canine Parainfluenza Virus, Str 2
Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 2
Imidacloprid + Moxidectin 2
Grapiprant 2
Moxidectin 1
Glucosamine 1
Canine Rabies Vaccine 1
Canine Vaccine 1
Caninie Vaccine 1
Fluralaner 1
Clodronate Disodium 1
Sarolaner 1
Milbemycin/Praziquantel 1
Vaccine 1

Walking on tiptoes Reaction Insights

22 reports name Walking on tiptoes; 4 recorded a death outcome (18.2% of reported events, not a population-level mortality rate). VeDDRA code: 2389.

By species: Dog (15 reports), Cat (6 reports), Horse (1 reports). By breed: Domestic Shorthair (4), Retriever - Labrador (4), Shepherd Dog - Australian (2).

Most co-reported drugs: Ivermectin + Pyrantel As Pamoate Salt (3 reports), Pyrantel Pamoate;Sarolaner (3 reports), Maropitant Citrate (3 reports), Gabapentin (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.