Reaction profile

The FDA adverse-event record for vaginal prolapse

30 FDA adverse-event reports reference vaginal prolapse (VeDDRA 819). See the species, breeds, and drugs most associated with it below.

30
reports citing this reaction
43.3%
death-coded share
Cattle
most-affected species
Melengestrol Acetate
most-associated drug
Verify with FDA CVM →
30
Total Reports
13
Deaths
43.3%
Death Rate

Species Most Affected

Cattle 26
Dog 2
Horse 1
Sheep 1

Breeds Most Affected

Mixed (Cattle) 12
Crossbred Bovine/Cattle 6
Aberdeen Angus 4
Cattle (other) 4
Quarter Horse 1
Crossbred Ovine/sheep 1
Terrier - Irish Soft-coated Wheaten 1
Spitz - German Pomeranian 1

Associated Drugs

Melengestrol Acetate 7
Progesterone 7
Testosterone Propionate;Estradiol Benzoate 4
Trenbolone Acetate;Estradiol Benzoate 4
Monensin Sodium 4
Tylosin Phosphate 4
Lubabegron 3
Estradiol, Testosterone 2
Estradiol Benzoate; Testosterone Propionate 2
Progesterone;Estradiol Benzoate 2
Estradiol Benzoate, Progesterone 1
Progesterone, Estradiol Benzoate, Tylosin Tartrate 1
Pergolide Mesylate 1
Zeranol 1
Estriol Tablets 1
Milbemycin Oxime + Spinosad 1
Nitenpyram 1
Estradiol Benzoate; Trenbolone Acetate 1
Progesterone; Estradiol Benzoate; Tylosin Tartrate 1
Bovine Rhinotracheitis Virus + Virus Diarrhea + Parainfluenza 3 + Respiratory Syncytial Virus + Mannheimia Haemolytica + Pasteurella Multocida Vaccine 1

Vaginal prolapse Reaction Insights

30 reports name Vaginal prolapse; 13 recorded a death outcome (43.3% of reported events, not a population-level mortality rate). VeDDRA code: 819.

By species: Cattle (26 reports), Dog (2 reports), Horse (1 reports). By breed: Mixed (Cattle) (12), Crossbred Bovine/Cattle (6), Aberdeen Angus (4).

Most co-reported drugs: Melengestrol Acetate (7 reports), Progesterone (7 reports), Testosterone Propionate;Estradiol Benzoate (4 reports), Trenbolone Acetate;Estradiol Benzoate (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.