Vacant

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VeDDRA Code: 2636

18 adverse event reports referencing this reaction

18
Total Reports
2
Deaths
1110.0%
Death Rate

Species Most Affected

Dog 14
Cat 4

Breeds Most Affected

Crossbred Canine/dog 4
Chihuahua 3
Beagle 2
Domestic Shorthair 2
Retriever - Labrador 1
Cat (other) 1
Poodle (unspecified) 1
Spaniel (unspecified) 1
Ridgeback - Rhodesian 1
Boxer (German Boxer) 1

Associated Drugs

Unspecified 17
Fluralaner Chew Tablets 3
Fluralaner 13.64% 12-Week Chew 3
Trilostane 2
Phenobarbital 2
Propofol 2
Amoxicillin Trihydrate;Clavulanate Potassium ( K-Clavulanate) 2
Meloxicam 2
Robenacoxib 2
Buprenorphine 2
Cefovecin Sodium 2
Milbemycin Oxime + Spinosad 1
Ivermectin + Pyrantel 1
Ivermectin / Pyrantel Tablets 1
Spinosad 1
Sarolaner 1
Same 1
Polysulfated Glycosaminoglycan 1
Levothyroxine 1
Phenylpropanolamine 1

Data Summary

Metric Value
Total reports referencing reaction 18
Reports with fatal outcome 2
Case-fatality rate (reported events) 1110.0%
Species observed 2
Breeds observed 11
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 2636.

Vacant Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 18 adverse event reports that reference Vacant as a reaction term, including 2 reports with a death outcome — a 1110.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 2636, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Vacant appears most frequently in reports for Dog (14 reports), Cat (4 reports) — with Dog dominating at 14 entries. Within those species, the breeds most often named alongside this reaction are Crossbred Canine/dog (4), Chihuahua (3), Beagle (2). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Vacant are Unspecified (17 reports), Fluralaner Chew Tablets (3 reports), Fluralaner 13.64% 12-Week Chew (3 reports), Trilostane (2 reports), with Unspecified appearing alongside this reaction in 17 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial