Reaction profile

The FDA adverse-event record for tumbling circling disease (see also ataxia at 'neurological')

19 FDA adverse-event reports reference tumbling circling disease (see also ataxia at 'neurological') (VeDDRA 370). See the species, breeds, and drugs most associated with it below.

19
reports citing this reaction
10.5%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
19
Total Reports
2
Deaths
10.5%
Death Rate

Species Most Affected

Dog 14
Cat 4
Horse 1

Breeds Most Affected

Chihuahua 3
Terrier - Yorkshire 2
Crossbred Canine/dog 2
Domestic Shorthair 2
Bichon Frise 1
Terrier (unspecified) 1
Dachshund - Miniature 1
Pit Bull 1
Horse (unknown) 1
Burmese 1

Associated Drugs

Milbemycin Oxime + Spinosad 3
Ivermectin + Pyrantel As Pamoate Salt 3
Afoxolaner 2
Selamectin 2
Betamethasone + Florfenicol + Terbinafine 2
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 2
Maropitant Citrate 2
Cyclosporine A 1
Minocycline 1
Vinegar, Water, Hydrogen Peroxide Ear Wash 1
Sevoflurane 1
Methylprednisolone 1
Betamethasone Spray 1
Varied Supplements And Homeopathic Remedies 1
Doxycycline 1
Chloramphenicol 1
Linezolid 1
Pentoxyfilline 1
Niacinamide 1
Desoxycorticosterone Pivalate 1

Tumbling circling disease (see also ataxia at 'Neurological') Reaction Insights

19 reports name Tumbling circling disease (see also ataxia at 'Neurological'); 2 recorded a death outcome (10.5% of reported events, not a population-level mortality rate). VeDDRA code: 370.

By species: Dog (14 reports), Cat (4 reports), Horse (1 reports). By breed: Chihuahua (3), Terrier - Yorkshire (2), Crossbred Canine/dog (2).

Most co-reported drugs: Milbemycin Oxime + Spinosad (3 reports), Ivermectin + Pyrantel As Pamoate Salt (3 reports), Afoxolaner (2 reports), Selamectin (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.