Reaction profile

The FDA adverse-event record for tracheal bleeding

16 FDA adverse-event reports reference tracheal bleeding (VeDDRA 877). See the species, breeds, and drugs most associated with it below.

16
reports citing this reaction
87.5%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
16
Total Reports
14
Deaths
87.5%
Death Rate

Species Most Affected

Dog 11
Cattle 3
Cat 1
Horse 1

Breeds Most Affected

Domestic Shorthair 1
Dachshund - Miniature 1
Chihuahua 1
Pug 1
Quarter Horse 1
Dog (unknown) 1
Terrier (unspecified) 1
Retriever - Chesapeake Bay 1
Bulldog - French 1
Beefmaster 1

Associated Drugs

Milbemycin Oxime + Spinosad 4
Moxidectin 3
Isoflurane 3
Dexmedetomidine Hydrochloride 2
Cefovecin 1
Antibiotic 1
Flea Collar Unknown 1
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 1
Detomidine Hydrochloride 1
Ivermectin + Pyrantel 1
Fentanyl 1
Dexmedetomidine 1
Morphine 1
Bupivacaine 1
Cefazolin 1
Eprinomectin 5% Injection 1
Merial La Polypropylene Syringe 1
Fluralaner Chew Tablets 1
Fenbendazol Suspension 1
Clostr Perf*2/Clos Others*6 Kb 1

Tracheal bleeding Reaction Insights

16 reports name Tracheal bleeding; 14 recorded a death outcome (87.5% of reported events, not a population-level mortality rate). VeDDRA code: 877.

By species: Dog (11 reports), Cattle (3 reports), Cat (1 reports). By breed: Domestic Shorthair (1), Dachshund - Miniature (1), Chihuahua (1).

Most co-reported drugs: Milbemycin Oxime + Spinosad (4 reports), Moxidectin (3 reports), Isoflurane (3 reports), Dexmedetomidine Hydrochloride (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.