Reaction profile

The FDA adverse-event record for toothache

Name: Toothache - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

12 FDA reports name toothache, a lower-volume reaction in the CVM extract (VeDDRA 1847). Plate stamps and neighbourhood peers follow.

#2403 of 2,481
by report volume (all reactions): 12
reports citing this reaction: 16.7%
death-coded share: Cat
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Toothache has 12 reports now versus 11 in that prior snapshot: 1 more (9.1%).

Report change: +1
Death-coded reports: +1
Death-coded share: +7.6 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Toothache changes

FDA AER · VeDDRA plate

Code 1847 VOL-TRACE

VOL-TRACE · DEATH-ELEV · BOTTOM-DECILE · PHOTO-FINISH · SPECIES-CAT · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-TRACE 12 reports
DEATH-ELEV 16.7%
BOTTOM-DECILE #2403/2481
PHOTO-FINISH Agitated state of mind
SPECIES-CAT Cat · 6
DRUG-LEAD Meloxicam · 3
DESK-WIDE 8 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Agitated state of mind (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Toothache

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around Toothache

What the FDA AER plate says about Toothache

Signature read: 12 reports place Toothache in the lower third of FDA AER volume (#2403 of 2,481). Report volume is lower-third scale: 12 named reports in the openFDA extract. 2 of 12 reports were death-coded (16.7% of named reports, not a population mortality rate). Nearest volume peer: Agitated state of mind (±0 reports). Lead species Cat (6). Lead co-reported drug Meloxicam (3).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Meloxicam appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Cat 6

Dog 4

Human 2

Breeds Most Affected

Domestic Shorthair 3

Unknown 2

Beagle 2

Domestic Longhair 1

Cat (unknown) 1

Ragdoll 1

Crossbred Canine/dog 1

Chihuahua 1

Associated Drugs

Meloxicam 3

Buprenorphine 3

Trilostane 3

Pimobendan 3

Cefovecin 2

Phenylpropanolamine Hydrochloride 2

Selamectin 1

Dolasetron 1

Robenacoxib 1

Propofol 1

Isoflurane 1

Bupivacaine 1

Cefazolin 1

Fluralaner Spot-On Solution 1

Device: Electrotherapy 1

Velagliflozin Proline Monohydrate 1

Bexagliflozin 1

Furosemide 1

Spironolactone 1

Benazepril 1

What to do with this reaction

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Toothache (#2403 of 2,481 by report volume); death-coded 16.7%. PlainBreed reaction plate · report volume stamp 12 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →