Reaction profile

The FDA adverse-event record for tic(s)

47 FDA adverse-event reports reference tic(s) (VeDDRA 685). See the species, breeds, and drugs most associated with it below.

47
reports citing this reaction
4.3%
death-coded share
Dog
most-affected species
Sarolaner
most-associated drug
Verify with FDA CVM →
47
Total Reports
2
Deaths
4.3%
Death Rate

Species Most Affected

Dog 42
Cat 4
Rabbit 1

Breeds Most Affected

Retriever - Labrador 10
Boxer (German Boxer) 3
Terrier - Yorkshire 3
Retriever - Golden 3
Dachshund (unspecified) 2
Schnauzer - Miniature 2
Spaniel (unspecified) 2
Domestic Shorthair 2
Dog (other) 1
American Pit Bull Terrier 1

Associated Drugs

Sarolaner 13
Milbemycin Oxime + Spinosad 10
Carprofen 7
Pyrantel Pamoate;Sarolaner 5
Bedinvetmab 5
Gabapentin 4
Spinosad 3
Ivermectin 2
Maropitant Citrate 2
Meloxicam 2
Cyclosporine 2
Clomipramine 2
Prednisone 2
Pregabalin 2
Furosemide 1
Pimobendan 1
Prednisolone Trimeprazine Tartrate 1
Cephalexin 1
Phycocyanin + Glucosamine + Methylsulfonylmethane + Minerals + Essential Fatty Acids 1
Ivermectin 272Mcg, Pyrantel 227Mg 1

Tic(s) Reaction Insights

47 reports name Tic(s); 2 recorded a death outcome (4.3% of reported events, not a population-level mortality rate). VeDDRA code: 685.

By species: Dog (42 reports), Cat (4 reports), Rabbit (1 reports). By breed: Retriever - Labrador (10), Boxer (German Boxer) (3), Terrier - Yorkshire (3).

Most co-reported drugs: Sarolaner (13 reports), Milbemycin Oxime + Spinosad (10 reports), Carprofen (7 reports), Pyrantel Pamoate;Sarolaner (5 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.