Reaction profile

The FDA adverse-event record for swelling around eye (see also immune system disorders)

27 FDA reports name swelling around eye (see also immune system disorders), a lower-volume reaction in the CVM extract (VeDDRA 461). Plate stamps and neighbourhood peers follow.

#2050 of 2,481
by report volume (all reactions)
27
reports citing this reaction
0.0%
death-coded share
Dog
most-affected species
Verify with FDA CVM →

FDA AER · VeDDRA plate

Code 461 VOL-TRACE

VOL-TRACE · DEATH-RARE · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 27 reports
  • DEATH-RARE 0.0%
  • LOWER-Q #2050/2481
  • PHOTO-FINISH Abortion spontaneous
  • SPECIES-DOG Dog · 23
  • DRUG-LEAD Lotilaner · 6
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Abortion spontaneous (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Swelling around eye

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Abortion spontaneous · near27Aplastic anaemia · near27Cyanotic spots/blotch… · near27Cyst rupture NOS · near27Swelling around eye (… · thi…27Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Swelling around eye (see also Immune system disorders)

Swelling around eye (see also Immune system disorders): low death-coded share in the FDA AER plate

Signature read: Swelling around eye (see also Immune system disorders)'s 0.0% death-coded share is among the lowest in the openFDA reaction corpus. Report volume is lower-third scale: 27 named reports in the openFDA extract. Death-coded share is lower-third: 0 of 27 reports (0.0% of named reports). Nearest volume peer: Abortion spontaneous (±0 reports). Lead species Dog (23). Lead co-reported drug Lotilaner (6).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Lotilaner appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 23
Cat 3
Human 1

Breeds Most Affected

Siberian Husky 2
Crossbred Canine/dog 2
Domestic Shorthair 2
Retriever - Golden 2
Terrier - Yorkshire 2
Chihuahua 2
Maltese 1
Spitz - German Pomeranian 1
Retriever - Labrador 1
Cat (unknown) 1

Associated Drugs

Lotilaner 6
Fluralaner Powder For Inj Susp 4
Rabies Vaccine 3
Bedinvetmab 3
Bordetella Vaccine 2
Lotilaner,Moxidectin,Praziquantel,Pyrantel Pamoate 2
Canine Influenza Virus H3 Rp 2
Moxidectin 2
Rabies Virus, Kv 2
Isoflurane 2
Canine Adenovirus, Type 2 Virus, V197 Strain,Canine Distemper Virus, Ondesterpoort Strain,Canine Parvovirus, Fd 2001 Strain 2
Oclacitinib Maleate 2
Allergy Supplement (Unknown) 1
Ivermectin + Pyrantel 1
Fluralaner 13.64% 12-Week Chew 1
Carprofen 1
Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Borrelia Burgdorferi Bacterin-Lepto Cani-Grippo-Ictero-Pomona Bacterial Extract 1
Ilunocitinib 1
Canine Distemper + Adenovirus Type 2 + Coronavirus + Parainfluenza + Parvovirus Vaccine 1
Milbemycin Oxime + Lufenuron + Praziquantel 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Swelling around eye (see also Immune system disorders) (#2050 of 2,481 by report volume); death-coded 0.0%. PlainBreed reaction plate · death-coded share stamp 0.0% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →