Reaction profile

The FDA adverse-event record for splenitis

14 FDA reports name splenitis, a lower-volume reaction in the CVM extract (VeDDRA 184). Plate stamps and neighbourhood peers follow.

#2339 of 2,481
by report volume (all reactions)
14
reports citing this reaction
64.3%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Splenitis has 14 reports now versus 14 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Splenitis changes

FDA AER · VeDDRA plate

Code 184 VOL-TRACE

VOL-TRACE · DEATH-HOT · BOTTOM-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 14 reports
  • DEATH-HOT 64.3%
  • BOTTOM-DECILE #2339/2481
  • PHOTO-FINISH Addisonian crisis
  • SPECIES-DOG Dog · 8
  • DRUG-LEAD Enrofloxacin · 2
  • DESK-WIDE 8 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Addisonian crisis (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Splenitis

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Addisonian crisis · near14Application site puru… · near14Bullous disorder NOS · near14Chapped skin · near14Splenitis · this reaction14Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Splenitis

Splenitis: high death-coded share in the FDA AER plate

Signature read: 14 reports place Splenitis in the lower third of FDA AER volume (#2339 of 2,481). Report volume is lower-third scale: 14 named reports in the openFDA extract. Death-coded share is upper-third: 9 of 14 reports (64.3% of named reports). Nearest volume peer: Addisonian crisis (±0 reports). Lead species Dog (8). Lead co-reported drug Enrofloxacin (2).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 8
Cat 3
Cattle 2
Tiger 1

Breeds Most Affected

Retriever - Labrador 4
Domestic Shorthair 3
Crossbred Bovine/Cattle 2
Retriever - Golden 1
Newfoundland 1
Unknown 1
Corgi - Welsh Cardigan 1
Shih Tzu 1

Associated Drugs

Enrofloxacin 2
Carprofen 2
Buprenorphine 2
Leptospirosis Vaccine 2
Spinosad 1
Firocoxib 227 Mg Chewable 1
Oxytetracycline 1
Moxidectin 1
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza3-Respiratory Syncytial Virus Vaccine, Modified Live Virus, Mannheimia Haemolytica Toxoid 1
Clostridium Chauvoei-Septicum-Novyi-Sordellii-Perfringens Types C And D-Moraxella Bovis Bacterin-Toxoid 1
Pimobendan 1
Deracoxib 1
Glucosamine + Chondroitin 1
Firocoxib 1
Eprinomectin + Praziquantel 1
Rabies Virus,Pv-11,Killed 1
Mirtazapine 1
Cefovecin Sodium 1
Penicillin G 1
Afoxolaner 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Splenitis (#2339 of 2,481 by report volume); death-coded 64.3%. PlainBreed reaction plate · report volume stamp 14 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →