Reaction profile

The FDA adverse-event record for splenitis

13 FDA adverse-event reports reference splenitis (VeDDRA 184). See the species, breeds, and drugs most associated with it below.

13
reports citing this reaction
61.5%
death-coded share
Dog
most-affected species
Enrofloxacin
most-associated drug
Verify with FDA CVM →
13
Total Reports
8
Deaths
61.5%
Death Rate

Species Most Affected

Dog 8
Cat 3
Cattle 1
Tiger 1

Breeds Most Affected

Retriever - Labrador 4
Domestic Shorthair 3
Retriever - Golden 1
Crossbred Bovine/Cattle 1
Newfoundland 1
Unknown 1
Corgi - Welsh Cardigan 1
Shih Tzu 1

Associated Drugs

Enrofloxacin 2
Carprofen 2
Buprenorphine 2
Leptospirosis Vaccine 2
Spinosad 1
Firocoxib 227 Mg Chewable 1
Oxytetracycline 1
Moxidectin 1
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza3-Respiratory Syncytial Virus Vaccine, Modified Live Virus, Mannheimia Haemolytica Toxoid 1
Clostridium Chauvoei-Septicum-Novyi-Sordellii-Perfringens Types C And D-Moraxella Bovis Bacterin-Toxoid 1
Pimobendan 1
Deracoxib 1
Glucosamine + Chondroitin 1
Firocoxib 1
Eprinomectin + Praziquantel 1
Rabies Virus,Pv-11,Killed 1
Mirtazapine 1
Cefovecin Sodium 1
Penicillin G 1
Afoxolaner 1

Splenitis Reaction Insights

13 reports name Splenitis; 8 recorded a death outcome (61.5% of reported events, not a population-level mortality rate). VeDDRA code: 184.

By species: Dog (8 reports), Cat (3 reports), Cattle (1 reports). By breed: Retriever - Labrador (4), Domestic Shorthair (3), Retriever - Golden (1).

Most co-reported drugs: Enrofloxacin (2 reports), Carprofen (2 reports), Buprenorphine (2 reports), Leptospirosis Vaccine (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.