Reaction profile

The FDA adverse-event record for spleen rupture

46 FDA reports name spleen rupture, a lower-volume reaction in the CVM extract (VeDDRA 183). Plate stamps and neighbourhood peers follow.

#1790 of 2,481
by report volume (all reactions)
46
reports citing this reaction
82.6%
death-coded share
Dog
most-affected species
Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Spleen rupture has 46 reports now versus 45 in that prior snapshot: 1 more (2.2%).

Report change
+1
Death-coded reports
+0
Death-coded share
−1.8 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Spleen rupture changes

FDA AER · VeDDRA plate

Code 183 VOL-TRACE

VOL-TRACE · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 46 reports
  • DEATH-HOT 82.6%
  • MID-PACK #1790/2481
  • PHOTO-FINISH Barbering
  • SPECIES-DOG Dog · 41
  • DRUG-LEAD Milbemycin Oxime… · 9
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Barbering (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Spleen rupture

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Barbering · near46Conjunctival irritati… · near46Gingival erythema · near46Nervousness · near46Spleen rupture · this reacti…46Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Spleen rupture

Spleen rupture: high death-coded share in the FDA AER plate

Signature read: Spleen rupture's 82.6% death-coded share is among the highest in the openFDA reaction corpus. Report volume is lower-third scale: 46 named reports in the openFDA extract. Death-coded share is upper-third: 38 of 46 reports (82.6% of named reports). Nearest volume peer: Barbering (±0 reports). Lead species Dog (41). Lead co-reported drug Milbemycin Oxime + Spinosad (9).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 41
Cat 3
Cattle 2

Breeds Most Affected

Dog (unknown) 7
Retriever - Labrador 6
Domestic Shorthair 3
Crossbred Canine/dog 3
Shepherd Dog - German 3
Retriever - Golden 2
Holstein-Friesian also known as Holstein 1
Terrier - Jack Russell 1
Poodle - Standard 1
Shepherd Dog - Australian 1

Associated Drugs

Milbemycin Oxime + Spinosad 9
Oclacitinib Maleate 8
Bedinvetmab 7
Fluralaner Chew Tablets 6
Ivermectin + Pyrantel As Pamoate Salt 5
Carprofen 4
Afoxolaner 3
Milbemycin Oxime 2
Monensin Sodium 1
Anesthetic 1
Cefovecin 1
Melarsomine Dihydrochloride Injection 1
Ivermectin + Pyrantel Pamoate 1
Multivitamin Supplement 1
Spinosad 1
Imidacloprid + Moxidectin 1
Cefpodoxime Proxetil 1
Immunotherapy 1
Fish Oil 1
Ivermectin 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Spleen rupture (#1790 of 2,481 by report volume); death-coded 82.6%. PlainBreed reaction plate · death-coded share stamp 82.6% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →