Reaction profile

The FDA adverse-event record for spasticity

31 FDA adverse-event reports reference spasticity (VeDDRA 701). See the species, breeds, and drugs most associated with it below.

31
reports citing this reaction
19.4%
death-coded share
Dog
most-affected species
Buprenorphine
most-associated drug
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31
Total Reports
6
Deaths
19.4%
Death Rate

Species Most Affected

Dog 18
Cat 12
Cattle 1

Breeds Most Affected

Domestic Shorthair 7
Shepherd Dog - Australian 3
Pointing Dog - Hungarian Short-haired (Vizsla) 3
Retriever - Golden 2
Greyhound - Italian 1
Dog (unknown) 1
Domestic Mediumhair 1
Cat (unknown) 1
Cattle (unknown) 1
Terrier - Yorkshire 1

Associated Drugs

Buprenorphine 6
Propofol 4
Isoflurane 3
Milbemycin Oxime + Spinosad 3
Pyrantel Pamoate;Sarolaner 3
Cefovecin Sodium 3
Maropitant Citrate 3
Spinosad 2
Sarolaner 2
Trazodone 2
Hydromorphone 2
Chlorpheniramine Maleate 1
Ivermectin Chewable 165Mcg 1
Dexmedetomidine Hydrochloride 1
Butorphanol 1
Cefovecin 1
Amoxicillin As Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate) 1
Fluconazole 1
Doramectin; Phenol 1
Tiletamine Hcl; Zolazapam Hcl 1

Spasticity Reaction Insights

31 reports name Spasticity; 6 recorded a death outcome (19.4% of reported events, not a population-level mortality rate). VeDDRA code: 701.

By species: Dog (18 reports), Cat (12 reports), Cattle (1 reports). By breed: Domestic Shorthair (7), Shepherd Dog - Australian (3), Pointing Dog - Hungarian Short-haired (Vizsla) (3).

Most co-reported drugs: Buprenorphine (6 reports), Propofol (4 reports), Isoflurane (3 reports), Milbemycin Oxime + Spinosad (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.