Reaction profile

The FDA adverse-event record for skin hyperplasia

14 FDA adverse-event reports reference skin hyperplasia (VeDDRA 2986). See the species, breeds, and drugs most associated with it below.

14
reports citing this reaction
14.3%
death-coded share
Dog
most-affected species
Frunevetmab
most-associated drug
Verify with FDA CVM →
14
Total Reports
2
Deaths
14.3%
Death Rate

Species Most Affected

Dog 9
Cat 5

Breeds Most Affected

Domestic Shorthair 3
Retriever - Labrador 2
Coonhound (unspecified) 1
Persian 1
Shepherd Dog (unspecified) 1
Retriever - Golden 1
Domestic Longhair 1
Shepherd Dog - German 1
Doberman Pinscher 1
Terrier - Irish Soft-coated Wheaten 1

Associated Drugs

Frunevetmab 3
Oclacitinib Maleate 3
Bedinvetmab 2
Enrofloxacin 2
Rabies Vaccine 2
Anti-Il31 Mab Mcs Lot #1283563 2
Rabacfosadine 1
Cyclosporine 1
Dexamethasone, Baytril, Antifungal Concoction For The Ear 1
Mometamax 1
Afoxolaner 150Mg / Moxidectin 720Mcg / Pyrantel 300Mg Chewable Tablet 1
Nystatin + Neomycin Sulfate + Thiostrepton + Triamcinolone Acetonide 1
Robenacoxib 1
Rabies Vaccine, Killed Virus 1
Feline Rhinotracheitis Calici Panleukopenia Vaccine, Killed Virus 1
Selamectin 1
Fluralaner 13.64% 12-Week Chew 1
Carprofen 1
Dasequin 1
Gabapentin 1

Skin hyperplasia Reaction Insights

14 reports name Skin hyperplasia; 2 recorded a death outcome (14.3% of reported events, not a population-level mortality rate). VeDDRA code: 2986.

By species: Dog (9 reports), Cat (5 reports). By breed: Domestic Shorthair (3), Retriever - Labrador (2), Coonhound (unspecified) (1).

Most co-reported drugs: Frunevetmab (3 reports), Oclacitinib Maleate (3 reports), Bedinvetmab (2 reports), Enrofloxacin (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.