Reaction profile

The FDA adverse-event record for skin emphysema

25 FDA adverse-event reports reference skin emphysema (VeDDRA 1201). See the species, breeds, and drugs most associated with it below.

25
reports citing this reaction
32.0%
death-coded share
Dog
most-affected species
Maropitant Citrate
most-associated drug
Verify with FDA CVM →
25
Total Reports
8
Deaths
32.0%
Death Rate

Species Most Affected

Dog 14
Cat 7
Horse 3
Cattle 1

Breeds Most Affected

Domestic Shorthair 4
Chihuahua 3
Crossbred Canine/dog 2
Boxer (German Boxer) 1
Domestic Mediumhair 1
Leonberger 1
Cattle (unspecified) 1
Standardbred (unspecified) 1
Sheepdog - Shetland 1
Dog (unknown) 1

Associated Drugs

Maropitant Citrate 4
Cefovecin 3
Isoflurane 3
Prednisone 3
Tigilanol Tiglate 3
Famotidine 3
Metronidazole 3
Gabapentin 3
Butorphanol 3
Trilostane 2
Buprenorphine 2
Robenacoxib 2
Diphenhydramine 2
Dexmedetomidine Hydrochloride 1
Fluoxetine Hcl 1
Meloxicam 1
Alprazolam 1
Ketamine 1
Firocoxib 1
Dinoprost Tromethamine 1

Skin emphysema Reaction Insights

25 reports name Skin emphysema; 8 recorded a death outcome (32.0% of reported events, not a population-level mortality rate). VeDDRA code: 1201.

By species: Dog (14 reports), Cat (7 reports), Horse (3 reports). By breed: Domestic Shorthair (4), Chihuahua (3), Crossbred Canine/dog (2).

Most co-reported drugs: Maropitant Citrate (4 reports), Cefovecin (3 reports), Isoflurane (3 reports), Prednisone (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.