Reaction profile

The FDA adverse-event record for skin emphysema

25 FDA reports name skin emphysema, a lower-volume reaction in the CVM extract (VeDDRA 1201). Plate stamps and neighbourhood peers follow.

#2076 of 2,481
by report volume (all reactions)
25
reports citing this reaction
32.0%
death-coded share
Dog
most-affected species
Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Skin emphysema has 25 reports now versus 25 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Skin emphysema changes

FDA AER · VeDDRA plate

Code 1201 VOL-TRACE

VOL-TRACE · DEATH-HOT · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 25 reports
  • DEATH-HOT 32.0%
  • LOWER-Q #2076/2481
  • PHOTO-FINISH Abnormal behaviour NOS
  • SPECIES-DOG Dog · 14
  • DRUG-LEAD Maropitant Citrate · 4
  • DESK-WIDE 19 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Abnormal behaviour NOS (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Skin emphysema

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Abnormal behaviour NOS · near25Buccal ulceration · near25Dizzy spell · near25Elevated serum lipids · near25Skin emphysema · this reacti…25Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Skin emphysema

Skin emphysema: high death-coded share in the FDA AER plate

Signature read: 25 reports place Skin emphysema in the lower third of FDA AER volume (#2076 of 2,481). Report volume is lower-third scale: 25 named reports in the openFDA extract. Death-coded share is upper-third: 8 of 25 reports (32.0% of named reports). Nearest volume peer: Abnormal behaviour NOS (±0 reports). Lead species Dog (14). Lead co-reported drug Maropitant Citrate (4).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 14
Cat 7
Horse 3
Cattle 1

Breeds Most Affected

Domestic Shorthair 4
Chihuahua 3
Crossbred Canine/dog 2
Boxer (German Boxer) 1
Domestic Mediumhair 1
Leonberger 1
Cattle (unspecified) 1
Standardbred (unspecified) 1
Sheepdog - Shetland 1
Dog (unknown) 1

Associated Drugs

Maropitant Citrate 4
Cefovecin 3
Isoflurane 3
Prednisone 3
Famotidine 3
Metronidazole 3
Tigilanol Tiglate 3
Gabapentin 3
Butorphanol 3
Trilostane 2
Buprenorphine 2
Robenacoxib 2
Diphenhydramine 2
Dexmedetomidine Hydrochloride 1
Fluoxetine Hcl 1
Meloxicam 1
Alprazolam 1
Ketamine 1
Firocoxib 1
Dinoprost Tromethamine 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Skin emphysema (#2076 of 2,481 by report volume); death-coded 32.0%. PlainBreed reaction plate · report volume stamp 25 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →