Reaction profile

The FDA adverse-event record for sheath oedema

Name: Sheath oedema - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

14 FDA reports name sheath oedema, a lower-volume reaction in the CVM extract (VeDDRA 2640). Plate stamps and neighbourhood peers follow.

#2338 of 2,481
by report volume (all reactions): 14
reports citing this reaction: 7.1%
death-coded share: Horse
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Sheath oedema has 14 reports now versus 14 in that prior snapshot: 0 the same number of (0.0%).

Report change: +0
Death-coded reports: +0
Death-coded share: −0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Sheath oedema changes

FDA AER · VeDDRA plate

Code 2640 VOL-TRACE

VOL-TRACE · DEATH-PAR · BOTTOM-DECILE · PHOTO-FINISH · SPECIES-HORSE · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-TRACE 14 reports
DEATH-PAR 7.1%
BOTTOM-DECILE #2338/2481
PHOTO-FINISH Addisonian crisis
SPECIES-HORSE Horse · 11
DRUG-LEAD Pergolide Mesylate · 6
DESK-WIDE 9 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Addisonian crisis (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Sheath oedema

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around Sheath oedema

Sheath oedema: low death-coded share in the FDA AER plate

Signature read: 14 reports place Sheath oedema in the lower third of FDA AER volume (#2338 of 2,481). Report volume is lower-third scale: 14 named reports in the openFDA extract. Death-coded share is lower-third: 1 of 14 reports (7.1% of named reports). Nearest volume peer: Addisonian crisis (±0 reports). Lead species Horse (11). Lead co-reported drug Pergolide Mesylate (6).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Pergolide Mesylate appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Horse 11

Dog 2

Cattle 1

Breeds Most Affected

Horse (unknown) 4

Quarter Horse 3

Paso Fino 1

Mixed (Cattle) 1

Horse (other) 1

Terrier - Bull - American Pit 1

Appaloosa 1

Pug 1

Anglo Arab 1

Associated Drugs

Pergolide Mesylate 6

N-Butylscopolaminium Bromide 1

Tulathromycin 1

Albendazole 1

Trenbolone Acetate;Estradiol Benzoate 1

Infectious Bovine Rhinotracheitis Virus(Ts), Rlb 106;Bovine Parainfluenza Virus 1

Ivermectin 1

Carprofen 1

Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 1

Firocoxib 1

Moxidectin 1

Diclazuril Oral Pellets 1

Ivermectin + Praziquantel 1

Pentosan Polysulfate Sodium 1

What to do with this reaction

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Sheath oedema (#2338 of 2,481 by report volume); death-coded 7.1%. PlainBreed reaction plate · report volume stamp 14 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →