Respiratory tract neoplasm NOS

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VeDDRA Code: 888

25 adverse event reports referencing this reaction

25
Total Reports
14
Deaths
5600.0%
Death Rate

Species Most Affected

Dog 22
Cat 3

Breeds Most Affected

Domestic Shorthair 3
Schnauzer - Miniature 2
Retriever - Labrador 2
Beagle 2
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 2
Saint Bernard Dog 2
Dog (unknown) 2
Spaniel - King Charles Cavalier 2
Chow Chow 1
Shepherd Dog - German 1

Associated Drugs

Spinosad 4
Oclacitinib Maleate 4
Gabapentin 4
Carprofen 3
Milbemycin Oxime + Spinosad 3
Trilostane 3
Afoxolaner 3
Cefovecin 2
Propofol 2
Isoflurane 2
Meloxicam 2
Hydromorphone Hcl 2
Diazepam 2
Grapiprant 2
Ivermectin 2
Polysulfated Glycosaminoglycan 2
Ursodiol 2
Pimobendan 2
Fentanyl 1
Atipamezole Hydrochloride 1

Data Summary

Metric Value
Total reports referencing reaction 25
Reports with fatal outcome 14
Case-fatality rate (reported events) 5600.0%
Species observed 2
Breeds observed 16
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 888.

Respiratory tract neoplasm NOS Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 25 adverse event reports that reference Respiratory tract neoplasm NOS as a reaction term, including 14 reports with a death outcome — a 5600.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 888, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Respiratory tract neoplasm NOS appears most frequently in reports for Dog (22 reports), Cat (3 reports) — with Dog dominating at 22 entries. Within those species, the breeds most often named alongside this reaction are Domestic Shorthair (3), Schnauzer - Miniature (2), Retriever - Labrador (2). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Respiratory tract neoplasm NOS are Spinosad (4 reports), Oclacitinib Maleate (4 reports), Gabapentin (4 reports), Carprofen (3 reports), with Spinosad appearing alongside this reaction in 4 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial