Reaction profile

The FDA adverse-event record for rattling chest

16 FDA adverse-event reports reference rattling chest (VeDDRA 853). See the species, breeds, and drugs most associated with it below.

16
reports citing this reaction
43.8%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
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16
Total Reports
7
Deaths
43.8%
Death Rate

Species Most Affected

Dog 12
Cat 4

Breeds Most Affected

Domestic Shorthair 3
Retriever - Labrador 2
Terrier - Yorkshire 2
Lhasa Apso 1
Shih Tzu 1
Boxer (German Boxer) 1
Domestic Mediumhair 1
Dachshund (unspecified) 1
Bulldog - French 1
Saint Bernard Dog 1

Associated Drugs

Milbemycin Oxime + Spinosad 3
Buprenorphine 3
Clindamycin 3
Enrofloxacin 2
Robenacoxib Nsaid 2
Lotilaner 2
Ivermectin 2
Verdinexor 2
Bedinvetmab 2
Firocoxib 2
Amantadine 2
Prednisolone Trimeprazine Tartrate 1
Emodepside + Praziquantel 1
Flumethrin-Imidacloprid 1
Orbafloxacin 1
Selamectin 1
Dexamethasone Sodium Phosphate 1
Lactated Ringers Solution 1
Prednisolone; Trimeprazine Tartrate 1
Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 1

Rattling chest Reaction Insights

16 reports name Rattling chest; 7 recorded a death outcome (43.8% of reported events, not a population-level mortality rate). VeDDRA code: 853.

By species: Dog (12 reports), Cat (4 reports). By breed: Domestic Shorthair (3), Retriever - Labrador (2), Terrier - Yorkshire (2).

Most co-reported drugs: Milbemycin Oxime + Spinosad (3 reports), Buprenorphine (3 reports), Clindamycin (3 reports), Enrofloxacin (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.