Reaction profile

The FDA adverse-event record for rattling chest

16 FDA reports name rattling chest, a lower-volume reaction in the CVM extract (VeDDRA 853). Plate stamps and neighbourhood peers follow.

#2286 of 2,481
by report volume (all reactions)
16
reports citing this reaction
43.8%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Rattling chest has 16 reports now versus 16 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Rattling chest changes

FDA AER · VeDDRA plate

Code 853 VOL-TRACE

VOL-TRACE · DEATH-HOT · BOTTOM-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 16 reports
  • DEATH-HOT 43.8%
  • BOTTOM-DECILE #2286/2481
  • PHOTO-FINISH Abdominal transudate
  • SPECIES-DOG Dog · 12
  • DRUG-LEAD Milbemycin Oxime… · 3
  • DESK-WIDE 12 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Abdominal transudate (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Rattling chest

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Abdominal transudate · near16Abnormal rectal palpa… · near16AMMONIA INCREASED, BL… · near16Application site gran… · near16Rattling chest · this reacti…16Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Rattling chest

Rattling chest: high death-coded share in the FDA AER plate

Signature read: 16 reports place Rattling chest in the lower third of FDA AER volume (#2286 of 2,481). Report volume is lower-third scale: 16 named reports in the openFDA extract. Death-coded share is upper-third: 7 of 16 reports (43.8% of named reports). Nearest volume peer: Abdominal transudate (±0 reports). Lead species Dog (12). Lead co-reported drug Milbemycin Oxime + Spinosad (3).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 12
Cat 4

Breeds Most Affected

Domestic Shorthair 3
Retriever - Labrador 2
Terrier - Yorkshire 2
Lhasa Apso 1
Shih Tzu 1
Boxer (German Boxer) 1
Domestic Mediumhair 1
Dachshund (unspecified) 1
Bulldog - French 1
Saint Bernard Dog 1

Associated Drugs

Milbemycin Oxime + Spinosad 3
Buprenorphine 3
Clindamycin 3
Enrofloxacin 2
Robenacoxib Nsaid 2
Lotilaner 2
Ivermectin 2
Verdinexor 2
Firocoxib 2
Bedinvetmab 2
Amantadine 2
Prednisolone Trimeprazine Tartrate 1
Emodepside + Praziquantel 1
Flumethrin-Imidacloprid 1
Orbafloxacin 1
Selamectin 1
Dexamethasone Sodium Phosphate 1
Lactated Ringers Solution 1
Prednisolone; Trimeprazine Tartrate 1
Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Rattling chest (#2286 of 2,481 by report volume); death-coded 43.8%. PlainBreed reaction plate · report volume stamp 16 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →