Reaction profile

The FDA adverse-event record for pr-multiple sites, edema

10 FDA adverse-event reports reference pr-multiple sites, edema (VeDDRA 99649). See the species, breeds, and drugs most associated with it below.

10
reports citing this reaction
100.0%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
10
Total Reports
10
Deaths
100.0%
Death Rate

Species Most Affected

Dog 6
Cat 2
Cattle 1
Horse 1

Breeds Most Affected

Domestic (unspecified) 2
Mastiff 2
Cattle (unknown) 1
Terrier - Yorkshire 1
Spaniel - Cocker American 1
Deutsche Dogge, Great Dane 1
Spitz - German Pomeranian 1
Quarter Horse 1

Associated Drugs

Carprofen 3
Milbemycin Oxime + Spinosad 3
Isoflupredone 1
Cefovecin Sodium 1
Spinosad 1
Clindamycin Hydrochloride 1
Propofol 1
Moxidectin 1
Maropitant Citrate 1
Gabapentin 1
Flunixin Meglumine 1

PR-MULTIPLE SITES, EDEMA Reaction Insights

10 reports name PR-MULTIPLE SITES, EDEMA; 10 recorded a death outcome (100.0% of reported events, not a population-level mortality rate). VeDDRA code: 99649.

By species: Dog (6 reports), Cat (2 reports), Cattle (1 reports). By breed: Domestic (unspecified) (2), Mastiff (2), Cattle (unknown) (1).

Most co-reported drugs: Carprofen (3 reports), Milbemycin Oxime + Spinosad (3 reports), Isoflupredone (1 reports), Cefovecin Sodium (1 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.