Reaction profile

The FDA adverse-event record for pr-joint(s), lesion(s)

10 FDA adverse-event reports reference pr-joint(s), lesion(s) (VeDDRA 99624). See the species, breeds, and drugs most associated with it below.

10
reports citing this reaction
80.0%
death-coded share
Dog
most-affected species
Tulathromycin
most-associated drug
Verify with FDA CVM →
10
Total Reports
8
Deaths
80.0%
Death Rate

Species Most Affected

Dog 4
Cattle 2
Horse 2
Cat 1
Pig 1

Breeds Most Affected

Cattle (other) 2
Retriever - Labrador 1
Schnauzer (unspecified) 1
Domestic Longhair 1
Hound - Basset 1
Thoroughbred 1
Pig (unknown) 1
Retriever - Golden 1
Unknown 1

Associated Drugs

Tulathromycin 2
Lufenuron + Milbemycin Oxime 1
Trilostane 1
Milk Thistle 1
Symptom Remedy 1
Remania 8 1
Pro Neurizine 1
Cefovecin 1
Feline Calicivirus, Strain F-9, Passage 7, Lot A; Feline Chlamydia Psittaci, Str 1
Ceftiofur Crystalline Free Acid 1
Oclacitinib Maleate 1
Selegiline Hcl 1
Bovine Parainfluenza Virus 3 (Ts), Rlb103 (Nl-Bk-6), Mlv; Bovine Respiratory Syn 1
Bovine Respiratory Syncytial Virus, 597-10 10Th Psg Strain 375; Bovine Viral Dia 1
Doramectin 1
Pergolide Mesylate 1
Ractopamine 1
Grapiprant 1
Sodium Hyaluronate 1

PR-JOINT(S), LESION(S) Reaction Insights

10 reports name PR-JOINT(S), LESION(S); 8 recorded a death outcome (80.0% of reported events, not a population-level mortality rate). VeDDRA code: 99624.

By species: Dog (4 reports), Cattle (2 reports), Horse (2 reports). By breed: Cattle (other) (2), Retriever - Labrador (1), Schnauzer (unspecified) (1).

Most co-reported drugs: Tulathromycin (2 reports), Lufenuron + Milbemycin Oxime (1 reports), Trilostane (1 reports), Milk Thistle (1 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.